Publications by authors named "Y Nakao"

Background/aim: Imeglimin, a novel oral antidiabetic agent, was approved in 2021 for the treatment of type 2 diabetes mellitus (T2DM). Phase III clinical trials demonstrated its safety and efficacy in managing T2DM. However, its safety profile in patients with heart failure has not been thoroughly evaluated in real-world clinical settings.

View Article and Find Full Text PDF

Social connections are essential for human health. While curiosity and empathy are crucial psychological factors for a fulfilling life connected with others, it is unclear if acquired environmental factors influence them. In this cross-sectional observational study, 1,311 men and women aged 20-79 years living in Japan were observed to explore how lifestyle factors such as diet, sleep, and leisure activities (such as exercise and hobbies) impact curiosity and empathy.

View Article and Find Full Text PDF
Article Synopsis
  • - The study investigates how impaired signaling in naïve CD4+ T cells leads to the development of pathogenic autoreactive cells, which play a role in autoimmune arthritis, specifically using SKG mice with a mutated Zap70 gene.
  • - Researchers found these pathogenic T cells had increased expression of activation and cytokine-related genes, but reduced expression of markers that usually promote tolerance compared to healthy cells.
  • - The presence of specific TCR variable beta chains linked to superantigens from mouse retroviruses suggests that these viral elements may disrupt normal immune tolerance, fostering the development of self-reactive CD4+ T cells into harmful effector cells, with potential therapeutic implications.
View Article and Find Full Text PDF

Reductive radical generation has become a cornerstone of modern photoredox chemistry. However, the synthesis of functionalized radical precursors remains a tedious multistep process. In this study, we focus on the potential of the nitro group as a redox-active functional group and present denitrative alkenylation of nitroalkanes, facilitated by photoreductive generation of alkyl radicals from nitroalkanes.

View Article and Find Full Text PDF

A PHP Error was encountered

Severity: Warning

Message: A non-numeric value encountered

Filename: controllers/Author.php

Line Number: 219

Backtrace:

File: /var/www/html/application/controllers/Author.php
Line: 219
Function: _error_handler

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: A non-numeric value encountered

Filename: libraries/Pagination.php

Line Number: 413

Backtrace:

File: /var/www/html/application/controllers/Author.php
Line: 274
Function: create_links

File: /var/www/html/index.php
Line: 316
Function: require_once