Background/aim: Imeglimin, a novel oral antidiabetic agent, was approved in 2021 for the treatment of type 2 diabetes mellitus (T2DM). Phase III clinical trials demonstrated its safety and efficacy in managing T2DM. However, its safety profile in patients with heart failure has not been thoroughly evaluated in real-world clinical settings.
View Article and Find Full Text PDFSocial connections are essential for human health. While curiosity and empathy are crucial psychological factors for a fulfilling life connected with others, it is unclear if acquired environmental factors influence them. In this cross-sectional observational study, 1,311 men and women aged 20-79 years living in Japan were observed to explore how lifestyle factors such as diet, sleep, and leisure activities (such as exercise and hobbies) impact curiosity and empathy.
View Article and Find Full Text PDFReductive radical generation has become a cornerstone of modern photoredox chemistry. However, the synthesis of functionalized radical precursors remains a tedious multistep process. In this study, we focus on the potential of the nitro group as a redox-active functional group and present denitrative alkenylation of nitroalkanes, facilitated by photoreductive generation of alkyl radicals from nitroalkanes.
View Article and Find Full Text PDF