Publications by authors named "Y Nagamine"
Objective: To identify generalism-related competencies that medical students in Japan should acquire in order to provide comprehensive care for patients.
Methods: The team responsible for developing the new 'Generalism' section of the 2022 revision of the Model Core Curriculum for Medical Education in Japan (MCC) consisted of nine members from diverse medical backgrounds across Japan. We adopted pragmatism paradigm and analyzed to identify decision-making processes using a qualitative document analysis.
Purpose: The application of immune checkpoint inhibitors (ICIs) can cause multi-organ adverse events, namely immune-related adverse events (irAEs) in patients with cancer. This study aimed to characterize the epidemiological information on irAEs in patients with cancer referred to the palliative care team (PCT).
Methods: The medical records of cancer patients with a history of ICI therapy referred to the PCT at a tertiary care center between January 2017 and July 2022 were retrospectively reviewed in this single-center, observational study.
Genomic studies of diseases can be divided into two types: i) analyses that reveal causal genes by focusing on linkage disequilibrium between observed and causal variants and ii) those that simultaneously assess numerous genetic markers to estimate the polygenic effects of a particular genomic region or entire genome. The field of human genetics has emphasized the discovery of causal genes, but these represent only a fraction of the total genetic variance. Therefore, alternative approaches, such as the polygenic risk score, which estimates the genetic risk for a given trait or disease based on all genetic markers (rather than on known causal variants only), have begun to garner attention.
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- A 78-year-old man with heart failure and severe mitral regurgitation underwent mitral valve replacement and coronary artery bypass grafting due to complex heart disease related to atheromatous aorta.
- The surgery was performed using mild hypothermia and systemic hyperkalemia while avoiding an aortic clamp to prevent neurological complications.
- The procedure was successful, and the patient had no neurological issues, being discharged 15 days post-surgery.
Background: The integration of the Internet into daily life has potential implications for public health, especially in promoting preventive healthcare measures like annual health checkups. This study explores the association between Internet use and the likelihood of participating in these checkups among older Japanese citizens.
Methods: Participants aged 65 and older were randomly selected from 37 municipalities in Japan, ensuring they required no long-term care.