Publications by authors named "Y Nabeya"
Objectives: The Cancer Control Act requires the maintenance of regional cooperation pathways (RCP) for cancer treatment. In 2008, we started RCP for early detection of new gastric cancer after endoscopic submucosal dissection (ESD). In gastric cancer treatment, RCP after surgical resection had been widely used, but little is known about RCP after ESD.
View Article and Find Full Text PDF[Significance of nutrition therapy in treatment of gastroenterological diseases].
Nihon Shokakibyo Gakkai Zasshi
June 2024
Article Synopsis
- Proton-based chemoradiotherapy (P-CRT) for esophageal squamous cell carcinoma (ESCC) demonstrated similar overall survival rates compared to the traditional surgery-based treatment (NAC-S) according to a multicenter Japanese study involving 518 patients.
- The 3-year overall survival rates were 74.8% for the P-CRT group and 72.7% for the NAC-S group, while the progression-free survival was lower for P-CRT (51.4%) compared to NAC-S (59.6%).
- The study suggests that P-CRT may be particularly beneficial as a first-line treatment for patients with stage I-II ESCC, showing a favorable survival advantage in earlier disease stages.
Article Synopsis
- A phase I/II study previously established an optimal carbon-ion radiotherapy (CIRT) dose for treating early-stage esophageal cancer, prompting further evaluation of its long-term efficacy and feasibility in a larger patient group.
- The retrospective study included 38 patients treated from 2012 to 2022, showing that all participants, including high-risk individuals, completed the CIRT regimen with manageable side effects, mainly grade 3 esophagitis and pneumonia.
- After five years, the study reported a 76.6% overall survival rate and confirmed that the recommended CIRT dose fractionation is both effective and feasible for patients with cT1bN0M0 esophageal squamous cell carcinoma.