Publications by authors named "Y N Spoorthy"
Article Synopsis
- Two series of bis pyrazolones were synthesized, featuring either a 3-methyl or a 3-amino substituent, through cyclization reactions between hydrazides and esters/cyano esters in an ethanolic solution.
- The structures of the new compounds were validated using elemental analysis, IR, (1)H NMR, and mass spectrometry techniques.
- The series with the 3-amino substituent exhibited superior antibacterial and antifungal activity compared to the series with the 3-methyl substituent, with specific compounds showing greater antimicrobial effectiveness than others.
The synthesis and characterization of new series of 1,4-benzodiazepine derivatives have been presented. The structures were confirmed by elemental analyses, IR spectral, (1)H NMR spectral and mass spectral data. All the compounds were screened for in vitro antimicrobial and anthelmintic activities.
View Article and Find Full Text PDFPurpose: This article makes an attempt to synthesize certain compounds containing thiazole and imidazole moieties and screen for the antimicrobial properties.
Methods: The novel compounds synthesized were characterized by elemental analysis, IR and (1)HNMR spectral data. The antimicrobial activity of novel compounds was evaluated by cup plate method.
Purpose: The aim of this article is to synthesize, characterize and evaluate the antimicrobial activity of certain novel 3-methyl-5-oxo-4-(phenyl hydrazono)-4,5-dihydro-pyrazol-1-yl]-acetic acid N|-(4-substituted thiazol-2-yl)-hydrazides.
Methods: The synthesized compounds were characterized by elemental analysis and IR, NMR and mass spectral data. The antimicrobial activity of novel compounds was evaluated by broth dilution method.
Background: A highly sensitive, specific and rapid LC-ESI-MS/MS method has been developed and validated for simultaneous quantification of amlodipine (AMD) and atenolol (ATL) in human plasma (200 µl) using AMD-d4 and ATL-d7, respectively, as an internal standard (IS) as per the regulatory guidelines.
Results: The SPE method was used to extract the analytes and IS from human plasma. The chromatographic resolution of AMD, ATL and corresponding IS was achieved using an isocratic flow on a C18 column.