Studying the pathogenicity of avian influenza virus subtype H5N1 strains from the Russian Federation using mouse model.

The pathogenicity of strains of avian influenza virus subtype H5N1 from the Russian Federation (A/turkey/Suzdalka/12/05, A/goose/Krasnoozerskoye/627/05, A/duck/Tuva/01/06, A/chicken/Reshoty/02/06, and A/chicken/Krasnodar/123/060) was studied in mice. Morphological and immunological characteristics of experimental viral infection with avian influenza virus subtype H5N1 were evaluated.

Novel conjugate of moxifloxacin and carboxymethylated glucan with enhanced activity against Mycobacterium tuberculosis.

Mycobacterium tuberculosis is an intracellular pathogen that persists within macrophages of the human host. One approach to improving the treatment of tuberculosis (TB) is the targeted delivery of antibiotics to macrophages using ligands to macrophage receptors. The moxifloxacin-conjugated dansylated carboxymethylglucan (M-DCMG) conjugate was prepared by chemically linking dansylcadaverine (D) and moxifloxacin (M) to carboxymethylglucan (CMG), a known ligand of macrophage scavenger receptors.