Characterising a New Sheep Model of Parkinson's Disease Using Unilateral Intracerebral Injection of 6-Hydroxydopamine Into the Substantia Nigra.

New therapeutic agents developed for treating neurological disorders are often tested successfully on rodents. Testing in an appropriate large animal model where there is longer lifespan and comparable brain size to humans should improve translational success and is frequently expected by regulatory bodies. In this project, we aimed to establish a novel sheep model of Parkinson's disease as a large-brained experimental model for translational research.

Nanomineralzyme as a novel sustainable class of nanozyme: Chalcopyrite-based nanozyme for the visual detection of total antioxidant capacity in citrus fruit.

Chemically-synthesized Nanozymes that are widely used as alternatives to enzymes face challenges such as high precursor costs, complex preparation processes, and limited catalytic efficiency. To overcome these drawbacks, we introduce naturally derived nanozymes, nanomineralzymes, as a promising alternative, offering benefits like affordability, cost-effectiveness, and scalability. Chalcopyrite (CP, CuFeS) was sourced from a mineral deposit, and CP nanoparticles were produced by milling.

Evaluation of medication appropriateness index in cardiovascular outpatient clinic: A cross-sectional study.

Background: Older adults often have polypharmacy and multimorbidity. Cardiovascular diseases (CVDs) are the most common multimorbidities in older adults and are linked to wide range of adverse drug effects and drug-related problems. The medication appropriateness index (MAI) has been widely used in several patient settings to assess Potentially Inappropriate Medication (PIM) prescribing in older adults.

Injury incidence and patterns among Dutch calisthenics athletes: a cross-sectional observational study.

Background: This study aimed to investigate the injury incidence rate among calisthenics athletes and explore the factors associated with injuries, including demographic and athlete characteristics, as well as injury patterns and skill levels.

Methods: We collected data from Dutch calisthenics athletes using an electronic questionnaire administered between February and March 2020. The inclusion criteria required participants to be calisthenics athletes willing to take part and aged over 18 years.

Effect of urinary tract infection on the outcome of the allograft in patients with kidney transplantation.

Background: Urinary tract infections (UTIs) are the second most common cause of graft dysfunction, accounting for significant morbidity, and are associated with poor graft and patient survival. This study aimed to assess the association between post-renal transplant UTI and graft outcomes.

Methods: We examined the effect of UTIs on graft outcomes in patients who underwent renal transplantation surgery between January 2010 and December 2022.