Publications by authors named "Y N'Guyen"
Objectives: To determine the Incremental Cost-Utility Ratio (ICUR) of cochlear implantation in the treatment of adult patients with single-sided deafness (SSD) and asymmetric hearing loss (AHL).
Methods: This prospective multicenter pragmatic study including a randomized controlled trial (RCT) enrolled 155 subjects with SSD or AHL. Subjects chose a treatment option between: abstention, Contralateral Routing Of the Signal hearing aids, Bone Conduction Device or Cochlear Implant (CI).
Article Synopsis
- A study analyzed 150 nasopharyngeal samples from outpatient cases in northeastern France during the emergence of the SARS-CoV-2 Omicron variant in December 2021, finding that only 3 samples (2%) were Omicron variants while 147 (98%) were delta variants.
- Phylogenetic analysis suggested that the early Omicron strains might have originated from South Africa or India, and an uncharacterized spike mutation (Y170W) was identified, which was weakly present during this period.
- The study concluded that a routine whole-genome sequencing approach is crucial for understanding and tracking the genotypic changes of SARS-CoV-2 variants, which could inform public health policies.
Article Synopsis
- The COVID-19 pandemic has significantly impacted the follow-up care of people living with HIV in N'djamena, Chad, particularly increasing the rates of loss to follow-up (LTFU) from 2019 to 2022.
- The highest incidence of LTFU occurred in the first quarter of 2020, prior to the reported cases of SARS-CoV-2 in the region, indicating early disruptions in care.
- Despite these challenges, the overall mortality among this population remained low and was not directly influenced by COVID-19 infection waves, highlighting the importance of maintaining HIV care during health crises.
We investigate spontaneous reports of IIH related to fluoroquinolones recorded in the French national pharmacovigilance database in order to detect a possible pharmacovigilance signal. The association between IIH risk and fluoroquinolone exposure was assessed using a case/non-case study. Between 1985 and July 2023, 17 reports of IIH after fluoroquinolone exposure were recorded.
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