Publications by authors named "Y Muramatsu"
Background: Higher levels of high-sensitivity C-reactive protein (hsCRP) are associated with increased risk of cardiovascular events in patients with coronary artery disease (CAD).
Aims: To elucidate the characteristics of coronary plaques in patients with CAD with high hsCRP levels.
Methods: A total of 793 consecutive patients with stable CAD who underwent optical coherence tomography (OCT) of the culprit vessel during percutaneous coronary intervention were included.
Background: Though efforts have been made toward standardizing access to quality cancer care in Japan, there are still geographical and institutional disparities in the level of cancer care availability. We investigated the utilization of cyclin-dependent kinase 4/6 inhibitors plus endocrine therapy (CDK4/6i+ET) as first-line (1 L) treatment for hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) advanced breast cancer (ABC) in Japan.
Research Design And Methods: This cross-sectional survey included physicians who had treated ≥3 1 L patients with HR+/HER2- ABC in the past year.
Article Synopsis
- Hypoxic-ischemic encephalopathy (HIE) is a serious condition leading to high mortality and neurological issues, currently only treatable with therapeutic hypothermia.
- A clinical trial was conducted using Muse cells (CL2020) in 9 neonates with moderate-to-severe HIE, who also received therapeutic hypothermia; safety and tolerability were the main goals.
- The trial found that CL2020 was safe, with no severe adverse effects and normal developmental outcomes in about 67% of patients, indicating a need for further research through a larger controlled study to confirm these results.
Article Synopsis
- Multi-locus imprinting disturbance (MLID) affects methylation in certain genes and has been identified in about 150 cases of imprinting disorders, with inadequate previous research on this condition aside from one study on specific syndromes.
- In a study of 783 patients, 29 individuals with confirmed epimutations displayed MLID, found in 12% of those with Beckwith-Wiedemann syndrome (BWS) and 5% with Silver-Russell syndrome (SRS), but not in other syndromes.
- Further analysis revealed abnormal methylation patterns and deleterious genetic variants in mothers of MLID patients, with around 50% of MLID patients experiencing neurodevelopmental delays or intellectual disorders, indicating
Pathophysiological significance of the p.E31G variant in RAC1 responsible for a neurodevelopmental disorder with microcephaly.
Biochim Biophys Acta Mol Basis Dis
January 2025
Article Synopsis
- RAC1 gene encodes a GTPase crucial for actin cytoskeleton and signaling, with mutations linked to a neurodevelopmental disorder causing brain and facial abnormalities.
- A new variant (p.E31G) was identified in a school-aged boy experiencing developmental delays and microcephaly.
- Biochemical tests show the p.E31G variant alters RAC1's activity and interacts poorly with PAK1, leading to impaired neuronal differentiation and axonal growth, suggesting it contributes to the patient’s condition.