Oxidative balance scores and gallstone disease: mediating effects of oxidative stress.

Background: Gallstone disease (GSD) is a prevalent gastrointestinal disorder, few studies have examined the combined effects of dietary and lifestyle factors on GSD. This study aims to investigate the relationship between oxidative balance score (OBS) and GSD, and explores the potential mediating role of oxidative stress.

Methods: Cross-sectional data from 6,196 participants in the NHANES 2017-2020 were analyzed.

The steric hindrance effect of Co porphyrins promoting two-electron oxygen reduction reaction selectivity.

A new Co 5,10,15,20-tetrakis(2',6'-dipivaloyloxyphenyl)porphyrin (1) with eight ester groups in all and ' positions of phenyl groups was designed, which displayed significantly improved 2e oxygen reduction reaction (ORR) selectivity compared with a 5,10,15,20-tetrakis(-dipivaloyloxyphenyl) porphyrin (2) without large steric groups. This work is significant to reveal the steric hindrance effect of metal porphyrins on electrocatalytic ORR selectivity.

The alterations of ocular surface metabolism and the related immunity inflammation in dry eye.

Background: Dry eye disease (DED) stands as a prominent ocular condition of global prevalence, emerging as a growing concern within public health. However, the underlying mechanisms involved in its pathogenesis remain largely unknown. In recent years, with the development of metabolomics, numerous studies have reported alterations in ocular surface metabolism in DED and offered fresh perspectives on the development of DED.