Publications by authors named "Y Motoki"

Article Synopsis
  • Immuno-oncology (IO) drugs are critical for cancer treatment, but older patients face safety issues, including higher hospitalization rates despite similar rates of immune-related adverse events (irAEs) compared to younger groups.* -
  • A study analyzing clinical data from 181 patients over 80 years old found that 35% experienced irAEs, with 19% discontinuing therapy; elevated eosinophil counts were identified as a significant risk factor for developing these events.* -
  • Overall, IO therapy is deemed safe for older patients, but those starting treatment with high eosinophil counts require careful monitoring.*
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We developed a simulation model for predicting pesticide concentrations in succeeding leafy vegetables (PostPLANT-Soil), which includes the process of pesticide uptake from plant roots. To validate the model, we compared pesticide concentrations simulated by the model with values measured from field experiments in an upland Andosol. The model validation showed that pesticide concentrations in the plant shoot were correlated with the concentrations in the soil solution rather than those of the water-extracted pesticides.

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We validated a simulation model (PostPLANT-Soil) for predicting pesticide concentrations in succeeding leafy vegetables reported in our first paper in this series, which includes the pesticide sorption process into plant roots. As a result of the model validation with the measured data from a plant uptake study in a growth chamber, the model successfully simulated the concentration changes of pesticides in a plant shoot. However, the simulated shoot concentrations for several pesticides were overestimated compared to the measured values.

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