Efficacy and safety of preservative-free anti-glaucomatous eye drops (dorzolamide/timolol) in ocular hypertension and/or glaucoma.

Purpose: This study evaluated the efficacy, safety, and tolerability of a single-dose, preservative-free (PF) Dorzolamide/Timolol combination (Twinzol-SDU).

Methods: A 3-month single-arm, multicenter, prospective cohort study was conducted in Egypt between January 2021 and October 2022 on previously diagnosed and controlled patients with ocular hypertension and/or glaucoma. Efficacy was assessed using the change in intraocular pressure (IOP) after 6 and 12 weeks.

Chemical and biological investigations on modified gemcitabine by nanoliposome structured on cholesterol, pectin, and phosphatidylcholine as an anticancer drug via a drug delivery system.

Gemcitabine hydrochloride (GEM) mimics one of the building blocks of DNA and RNA, so it indicates possible chemotherapeutic effects. It prevents cancer cells from producing DNA and proteins, which ultimately leads to their death. The goal of this work is to modify the GEM medication by nanoforming nanoliposomes based on the composition of Cholesterol, pectin nanoparticles, and phosphatidylcholine (PhC).

Pulmonary hypertension post-liver transplant: A case report.

Background: Liver transplantation (LTx) is vital in patients with end-stage liver disease, with metabolic dysfunction-associated steatotic liver disease being the most common indication. Primary sclerosing cholangitis (PSC) is an important indication. Portopulmonary hypertension, associated with portal hypertension, poses a significant perioperative risk, making pretransplant screening essential.

Design, synthesis, and antiproliferative activity of new 1,2,3-triazole/quinazoline-4-one hybrids as dual EGFR/BRAF inhibitors.

A novel series of 1,2,3-triazole/quinazoline-4-one hybrids (8a-t) were designed and synthesized as dual-targeted antiproliferative agents. Compounds 8a-t were evaluated for their antiproliferative efficacy against a panel of four cancer cell lines. The results indicated that most of the evaluated compounds exhibited strong antiproliferative activity, with 8f, 8g, 8h, 8j, and 8l demonstrating the highest potency.