Simultaneous removal of nitrate, carbamazepine, and copper by fulvic acid and ferric chloride composite modified ceramsite assembled fixed biofilter reactor: Performance and microbial community response.

The complex pollution and nutrient-poor characteristics of surface waters result in the limited ability of conventional reactors to remove pollutants. In this study, a novel modified ceramsite material, modified with trivalent iron (Fe(III)) and fulvic acid (FA) to form ceramsite@Fe(III)@FA (HC), was used for the first time as a biocarrier to immobilize strain Cupriavidus sp. W12, constructing a biofilter to enhance nitrate (NO-N) removal in micro-polluted water.

MI-Mamba: A hybrid motor imagery electroencephalograph classification model with Mamba's global scanning.

Deep learning has revolutionized electroencephalograph (EEG) decoding, with convolutional neural networks (CNNs) being a predominant tool. However, CNNs struggle with long-term dependencies in sequential EEG data. Models like long short-term memory and transformers improve performance but still face challenges of computational efficiency and long sequences.

TDP43 augments astrocyte inflammatory activity through mtDNA-cGAS-STING axis in NMOSD.

Abnormality in transactivating response region DNA binding protein 43 (TDP43) is well-recognized as the pathological hallmark of neurodegenerative diseases. However, the role of TDP43 in neuromyelitis optica spectrum disorder (NMOSD) remains unknown. Here, our observations demonstrate an upregulation of TDP43 in both in vitro and in vivo models of NMOSD, as well as in biological samples from NMOSD patients.

The accumulation of harmful genes within the ROH hotspot regions of the Tibetan sheep genome does not lead to genetic load.

Background: Prolonged natural selection and artificial breeding have contributed to increased uniformity within the Tibetan sheep population, resulting in a reduction in genetic diversity and the establishment of selective signatures in the genome. This process has led to a loss of heterozygosity in specific genomic regions and the formation of Runs of Homozygosity (ROH). Current research on ROH predominantly focuses on inbreeding and the signals of selection; however, there is a paucity of investigation into the genetic load and selective pressures associated with ROH, both within these regions and beyond.

First-line cadonilimab plus chemotherapy in HER2-negative advanced gastric or gastroesophageal junction adenocarcinoma: a randomized, double-blind, phase 3 trial.

Programmed cell death protein-1 (PD-1) inhibitors plus chemotherapy have been the standard of care in the first-line treatment of advanced gastric or gastroesophageal junction (G/GEJ) adenocarcinoma; however, the survival benefits are modest in patients with low programmed death ligand 1 (PD-L1) expression. Here we investigated the efficacy and safety of cadonilimab (PD-1/cytotoxic T lymphocyte antigen-4 (CTLA-4) bispecific antibody) plus chemotherapy as first-line treatment in G/GEJ adenocarcinoma. The prespecified interim analysis is reported here.