Redox-activatable inhalable mucoadhesive proteinic nanotherapeutics for targeted treatment of lung cancer.

Inhalation delivery has been considered a promising choice for treating lung cancer because it can shuttle therapeutic payloads directly to cancer tissues via simple and noninvasive procedures while reducing systemic toxicity. However, its clinical application still faces challenges, especially for delivering hydrophobic chemotherapeutic drugs, due to poor absorption on mucosal tissues and limited therapeutic performance. Herein, we propose inhalable mucoadhesive proteinic nanoparticles (NPs) capable of facilitating reliable pulmonary drug delivery and redox-responsive anticancer therapeutic effects to realize noninvasive, localized treatment of lung cancer in a highly biocompatible, site-specific manner.

Rice OsDof12 enhances tolerance to drought stress by activating the phenylpropanoid pathway.

Drought is a major abiotic stress that severely affects cereal production worldwide. Although several genes have been identified that enhance the ability of rice to withstand drought stress, further research is needed to fully understand the molecular mechanisms underlying the response to drought stress. Our study showed that overexpression of rice DNA binding with one finger 12 (OsDof12) enhances tolerance to drought stress.

UG0712, A Ginsenoside Complex, Improved Endurance Performance and Changed Hepatic and Muscular Transcriptomic Signatures in C57BL/6N Male Mice.

Ginsenosides, active compounds derived from Panax ginseng, exhibit promising potential in enhancing physical performance. This study investigates the impact of UG0712 (UG), a novel ginsenoside compound, on endurance capacity, body weight, organ weights, blood parameters, and specific transcriptomic changes in liver and muscle tissues using a C57BL/6N mouse model. The mice received UGs orally at three doses: UG50 (50 mg/kg), UG100 (100 mg/kg), and UG200 (200 mg/kg) for a specified duration.

Hypertension prevalence in Korean adolescents according to parental hypertension: data from the Korea National Health and Nutrition Survey.

The prevalence of hypertension among children and adolescents has risen to 4% globally in recent decades, presenting a significant public health challenge due to its association with increased cardiovascular risks. Existing research on the transmission of hypertension risk between parents and offspring lacks comprehensive data from general population-based samples with clinically collected measurements spanning generations. This study utilized nationally representative data to assess the risk of developing hypertension in offspring based on parental hypertension status, employing standardized blood pressure measurements rather than relying solely on historical data.

Corrigendum: Prognostic significance of FDG PET/CT in esophageal squamous cell carcinoma in the era of the 8th AJCC/UICC staging system.

[This corrects the article DOI: 10.3389/fonc.2022.