A polyvalent vaccine for selectively killing tumor-associated bacteria to prevent cancer metastasis.

Specific bacteria, including , , , and , have been identified as contributors to breast cancer metastasis. Due to limitations such as lack of selectivity, traditional antibiotic therapies face obstacles in eliminating intratumoral bacteria. Herein, this work proposes the use of therapeutic vaccines to selectively target and eliminate harmful bacteria within tumors.

Ergosterol originated from attenuates high fat diet-induced obesity and cognitive impairment in mice.

Excessive intake of a high fat diet (HFD) leads to accumulation of fat and obesity. Ergosterol (ERG) is a characteristic sterol of fungi with various bioactive functions; however, there are few studies on the ERG function of ameliorating obesity and following cognitive impairment. It was previously found that Zhashui (AA) is rich in ERG; therefore it was selected to enrich ERG through the intervention of exogenous inducers of rice bran oil (RBO), methyl jasmonate (Me JA) and salicylic acid (SA).

A p-n heterojunction sonosensitizer for improved sono-immunotherapy via induction of multimodal cell death mechanisms.

Activating a robust immune system is a crucial strategy for combating solid tumors and preventing recurrences. Studies have shown that cuproptosis and the resulting increased reactive oxygen species (ROS) can trigger immunogenic cell death (ICD) and modulate the tumor immune microenvironment, thereby activating systemic immunity. Therefore, for this purpose, it is important to design a multifunctional copper-based nanomaterial.

promoter hypomethylation correlates with enhanced immune cell infiltration, favorable prognosis, and immunotherapy response in melanoma.

Background: Immune checkpoint blockade (ICB)-based immunotherapy has significantly improved survival in advanced melanoma. However, many patients exhibit resistance to these therapies. This study examines the impact of promoter methylation on its expression, immune cell infiltration, and clinical outcomes, evaluating its potential as a prognostic and predictive biomarker for immunotherapy response.

Prediction of chicken breast meat freshness based on hyperspectral imaging technique and high-throughput sequencing.

In this article, the hyperspectral imaging technique and the high-throughput sequencing were combined to construct prediction models for the freshness of chicken breast meat. The quality indicators including color, pH, TVC, TVB-N and TBARS were measured to reflect the freshness changes of chicken breast meat under 4 ℃ storage. Meanwhile, spectral images of chicken breast meat were obtained using visible near-infrared (400-1,000 nm) hyperspectral imaging.