Azithromycin-resistant mph(A)-positive Salmonella enterica serovar Typhi in the United States.

Objectives: The United States Centers for Disease Control and Prevention (CDC) conducts active surveillance for typhoid fever cases caused by Salmonella enterica serovar Typhi (Typhi). Here we describe the characteristics of the first two cases of mph(A)-positive azithromycin-resistant Typhi identified through US surveillance.

Methods: Isolates were submitted to public health laboratories, sequenced, and screened for antimicrobial resistance determinants and plasmids, as part of CDC PulseNet's routine genomic surveillance.

promotes pain-reducing metabolomic reprogramming in cutaneous lesions.

Cutaneous leishmaniasis (CL) is characterized by extensive skin lesions, which are usually painless despite being associated with extensive inflammation. The molecular mechanisms responsible for this analgesia have not been identified. Through untargeted metabolomics, we found enriched anti-nociceptive metabolic pathways in -infected mice.

Enhanced vs conventional monofocal intraocular lens clinical results in patients with cataract: randomized clinical trial.

Purpose: To compare clinical outcomes between an enhanced and a conventional monofocal intraocular lens (IOL) after cataract surgery.

Setting: Ophthalmology Unit, Hospital del Salvador, University of Chile (tertiary care hospital).

Design: Double-masked, prospective randomized controlled trial.

Prevalence of refractive errors in children of Puerto Rico.

Aim: To determine the prevalence of refractive error in 5- to 17-year-old schoolchildren in Puerto Rico.

Methods: A quantitative descriptive study of 2867 children aged 5 to 17y from all seven educational regions of Puerto Rico was conducted from 2016-2019. Refractive error was determined static and subjective refraction.

A two-stage stochastic optimization model for the retail multiskilled personnel scheduling problem: a k-chaining policy with k≥2.

Considering an uncertain demand, this study evaluates the potential benefits of using a multiskilled workforce through a k-chaining policy with k≥2. For the service sector and, particularly for the retail industry, we initially propose a deterministic mixed-integer linear programming model that determines how many employees should be multiskilled, in which and how many departments they should be trained, and how their weekly working hours will be assigned. Then, the deterministic model is reformulated using a two-stage stochastic optimization (TSSO) model to explicitly incorporate the uncertain personnel demand.