Cardiopulmonary Exercise Testing in Children and Adolescents with Repaired Tetralogy of Fallot: Mechanisms of Exercise Intolerance and Clinical Implications.

By comparison with adults, cardiopulmonary exercise testing in children with Tetralogy of Fallot is limited, and its clinical application less clarified. This study provides a comprehensive CPET profile in a child-adolescent population with repaired TOF, explores mechanisms underpinning exercise intolerance and associations with clinical outcome. Seventy-four CPETs were completed in 58 child-adolescents with rTOF (age 13.

Comprehensive study on the Python-based regression machine learning models for prediction of uniaxial compressive strength using multiple parameters in Charnockite rocks.

The strength of rock under uniaxial compression, commonly known as Uniaxial Compressive Strength (UCS), plays a crucial role in various geomechanical applications such as designing foundations, mining projects, slopes in rocks, tunnel construction, and rock characterization. However, sampling and preparation can become challenging in some rocks, making it difficult to determine the UCS of the rocks directly. Therefore, indirect approaches are widely used for estimating UCS.

Association Between Monocyte-to-High-Density Lipoprotein (HDL) Cholesterol Ratio and Proteinuria in Patients With Type 2 Diabetes Mellitus: A Prospective Observational Study.

Background Diabetes mellitus (DM) refers to a group of metabolic disorders that share the phenotype of hyperglycemia. "Diabetic nephropathy (DN)" is a microvascular complication of DM, and it is the leading cause of end-stage renal failure. Increased urinary albumin excretion (UAE) and a decrease in glomerular filtration rate (GFR) are associated with DN along with elevated blood pressure and end-stage renal disease (ESRD).

Sperm DNA Fragmentation Index and Intracytoplasmic Sperm Injection Outcome in Egyptian Couples.

Sperm of infertile men mostly contain more DNA damage than their fertile counterparts. Sperm DNA damage might have a negative effect on the fertility potential of such patients. This study measures the percentage of spermatozoa with nuclear DNA fragmentation in semen samples used for intacytoplasmic sperm injection (ICSI), before and after sperm processing and investigates the association between sperm DNA fragmentation index (DFI) and ICSI outcome (embryo grade and clinical pregnancy).