Publications by authors named "Y Maugars"

Article Synopsis
  • The study aimed to compare the effectiveness of an intradiscal injection of allogeneic bone marrow mesenchymal stromal cells (BM-MSCs) to a sham placebo in chronic low back pain patients.
  • 114 participants were randomly assigned to receive either the BM-MSC injection or a placebo, and outcomes were measured over 12 months using pain and disability scales, along with MRI assessments.
  • The results showed no significant difference in effectiveness between the BM-MSC and placebo groups after 12 months, although the procedure was deemed safe with no serious adverse events reported.
View Article and Find Full Text PDF
Article Synopsis
  • The study focuses on SB5, an adalimumab biosimilar approved in Europe in 2017, and aims to gather real-world data on its usage and effectiveness in patients with various immune-mediated inflammatory diseases (IMIDs).
  • Researchers analyzed clinical and healthcare claims data from the French national healthcare database to assess patient persistence on SB5 after 12 months.
  • Among 911 patients treated with SB5, notable remission rates were observed at the 12-month mark, particularly in naïve patients, across various conditions such as rheumatoid arthritis and Crohn's disease, with all showing significant improvement from baseline.
View Article and Find Full Text PDF

Boronate ester (BE) hydrogels are increasingly used for biomedical applications. The dynamic nature of these molecular networks enables bond rearrangement, which is associated with viscoelasticity, injectability, printability, and self-healing, among other properties. BEs are also sensitive to pH, redox reactions, and the presence of sugars, which is useful for the design of stimuli-responsive materials.

View Article and Find Full Text PDF

Introduction: Hypophosphatasia (HPP) is a rare genetic disease caused by loss-of-function mutations in the ALPL gene encoding the tissue non-specific alkaline phosphatase (ALP). Mild HPP is usually misdiagnosed in adult age. While an elevated serum ALP value draws more attention than a low value, low serum ALP should be better recognised and may lead to HPP detection.

View Article and Find Full Text PDF