Publications by authors named "Y Masuo"
Background: Food-derived nucleic acids exhibit various biological activities and may act as nutrients. Oral ingestion of the nucleic acid fraction (NAF) of salmon milt extract hydrolysates enhances cognitive function in mice, although their active ingredients have not yet been identified, and detailed mechanisms of action are unknown.
Objectives: To identify active ingredients enhancing cognitive function contained in the NAF and its possible underlying mechanism.
Cardiotoxicity associated with hepatic metabolism and drug-drug interactions is a serious concern. Predicting drug toxicity using animals remains challenging due to species and ethical concerns, necessitating the need to develop alternative approaches. Drug cardiotoxicity associated with hepatic metabolism cannot be detected using a cardiomyocyte-only evaluation system.
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- * A case study presented a 77-year-old man diagnosed with mixed neuroendocrine prostate cancer, showing high levels of specific tumor markers and multiple metastases.
- * Remarkably, the patient responded positively to a new triplet therapy combining darolutamide, androgen deprivation, and docetaxel, resulting in reduced tumor size and lower serum markers, marking a potential breakthrough in treatment.
Metabolic abnormalities play a pivotal role in various pathological conditions, necessitating the quantification of specific metabolites for diagnosis. While mass spectrometry remains the primary method for metabolite measurement, its limited throughput underscores the need for biosensors capable of rapid detection. Previously, we reported that pillar[6]arene with 12 carboxylate groups (P6AC) forms host-guest complexes with 1-methylnicotinamide (1-MNA), which is produced in vivo by nicotinamide -methyltransferase (NNMT).
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- Oral administration of the antioxidant amino acid ergothioneine (ERGO) improves cognitive function and promotes neurogenesis in the brain, particularly in the hippocampus.
- Mice fed an ERGO-free diet showed decreased cognitive function and neurogenesis, but these effects were reversed with ERGO supplementation, suggesting ERGO's crucial role in brain health.
- The study indicates that TrkB receptor phosphorylation is essential for ERGO’s cognitive benefits, with higher levels of phosphorylated TrkB in serum extracellular vesicles from humans taking ERGO, correlating with improved cognitive performance.