Publications by authors named "Y Mano"
Background: With the rise in the older population, it has become important to understand the relationship between oral frailty and drug use to consider appropriate medical interventions and drug use for older persons.
Objective: To clarify the relationship among oral frailty, drug use, and other patient backgrounds and to identify relevant factors using information from patient questionnaires and pharmacy medication history records.
Methods: This cross-sectional study involved community-dwelling older adults.
Article Synopsis
- - The study investigates how splenic vein occlusion (SpVO) from pancreatic tumors affects surgical outcomes and complications in patients undergoing distal pancreatectomy (DP).
- - Out of 124 patients analyzed, 20.8% had SpVO, leading to longer surgery times and more postoperative complications compared to those with open splenic veins.
- - The findings suggest that understanding collateral circulation patterns can aid in better surgical planning to minimize complications related to left-sided portal hypertension caused by SpVO.
Article Synopsis
- E3112 is a new human growth factor drug being tested for treating acute liver failure, with a focus on immunogenicity during its development.
- A specialized assay was created to measure anti-drug antibodies (ADA) in rats and monkeys, using a detailed validation process to ensure accuracy and reliability.
- Results showed that E3112 administration increased ADA levels, particularly in rats, and higher ADA levels were linked to lower drug exposure, helping researchers understand drug interactions and individual differences in response.
Pharmacokinetic profiles of methylcobalamin in rats after multiple administration routes by a simple LC-MS/MS assay with a small volume of plasma.
J Pharmacol Toxicol Methods
September 2024
Methylcobalamin (MBL) is a vitamin B12 coenzyme and is effective for treating peripheral neuropathies. Little is known about pharmacokinetics (PK) of MBL in animals, we have developed a simple assay for MBL by using only 0.01 mL of plasma for PK of MBL in rats.
View Article and Find Full Text PDFNeutrophil extracellular traps (NETs) released from neutrophils are related to cancer progression. However, the relationship between the therapeutic effects of immune checkpoint inhibitors (ICIs) such as anti-PD-1 and anti-PD-L1 antibodies and plasma NET concentration in patients with non-small cell lung cancer (NSCLC) is poorly understood. In this study, concentrations of citrullinated histone H3 (CitH3), a surrogate marker of NETs, in plasma before/after treatment were examined in patients with advanced or recurrent NSCLC undergoing ICI treatment (n = 185).
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