The impact of cold spells and heat waves frequencies on the prevalence and incidence of stroke in middle-to-elderly age population in China: evidence from the China Health and Retirement Longitudinal Study (CHARLS).

Stroke, a key cardiovascular disease, is impacted by cold spells and heat waves. However, limited sample size and unclear impact on the aging population's prevalence and incidence remain concerns. We aim to explore the association between cold spells and heat waves frequency and stroke in middle-aged and elderly people in China.

Dose determination of VV116 in COVID-19 patients with severe liver dysfunction: a case report.

VV116 is an oral antiviral drug against SARS-CoV-2, known for its favorable efficacy and safety profile. But its application in patients with severe liver dysfunction has not been evaluated. Here, we report a case in which a patient with aplastic anemia and liver impairment (recovery phase of acute liver failure) was infected with SARS-CoV-2.

Increasing RB1 Expression by Targeting EZH2 in Triple-Negative Breast Cancer.

Loss of RB1 function represents a defining characteristic of triple-negative breast cancer (TNBC) and is intricately associated with resistance to therapeutic interventions. In this study, we investigate the epigenetic mechanisms governing RB1 expression in TNBC. Employing a combination of bioinformatics analyses and experimental validations, we identified lysine histone methyltransferase EZH2 as a key upstream regulator of RB1 expression.

Incidence and clinical characteristics of occult inguinal hernias: a retrospective analysis of laparoscopic repair.

Background: Occult inguinal hernia is a unique clinical challenge characterized by asymptomatic presentation and the absence of detectable signs on physical examination, leading to frequent misdiagnosis and underdiagnosis. The advancement of laparoscopic hernia surgery has facilitated the identification of occult hernias, yet effective diagnostic and predictive methods remain lacking.

Objective: This study aims to evaluate the incidence and clinical characteristics of occult inguinal hernias detected during laparoscopic unilateral inguinal hernia repair and to provide evidence-based recommendations for their management.

A critical review of the ecotoxic effects of microplastics on aquatic, soil and atmospheric ecosystems and current research challenges.

The extensive use of plastics has brought unparalleled convenience to human social development. However, this has also led to severe environmental and health challenges, with microplastic (MP) pollution emerging as one of the most pressing issues. As ubiquitous environmental pollutants, MPs persist in ecosystems and pose potential risks to both ecological and human health.