Publications by authors named "Y M Pers"
Background: The regenerative potential of mesenchymal stromal/stem cells (MSCs) has been extensively studied in clinical trials in the past decade. However, despite the promising regenerative properties documented in preclinical studies, for instance in osteoarthritis (OA), the therapeutic translation of these results in patients has not been fully conclusive. One factor contributing to this therapeutic barrier could be the presence of senescent cells in OA joints.
View Article and Find Full Text PDF: Chronic low back pain (CLBP) is a common condition with limited long-term treatment options. Vagus nerve stimulation (VNS) has shown potential for pain improvement, but its use in CLBP remains underexplored. Our aim was to evaluate the efficacy, feasibility and tolerability of transcutaneous auricular vagus nerve stimulation (taVNS) in reducing pain and improving functional outcomes in CLBP patients.
View Article and Find Full Text PDFAlthough senescent cells can be eliminated by the immune system, they tend to accumulate with age in various tissues. Here we show that senescent cells can evade immune clearance by natural killer (NK) cells by upregulating the expression of the disialylated ganglioside GD3 at their surface. The increased level of GD3 expression on senescent cells that naturally occurs upon aging in liver, lung, kidney or bones leads to a strong suppression of NK-cell-mediated immunosurveillance.
View Article and Find Full Text PDFBackground: Despite efforts to improve undergraduate clinical pharmacology & therapeutics (CPT) education, prescribing errors are still made regularly. To improve CPT education and daily prescribing, it is crucial to understand how therapeutic reasoning works. Therefore, the aim of this study was to gain insight into the therapeutic reasoning process.
View Article and Find Full Text PDFArticle Synopsis
- - The French Society of Rheumatology and the French Society of Physical Medicine and Rehabilitation aimed to create recommendations for non-drug treatments for knee osteoarthritis due to their inadequate consideration in care.
- - A systematic review of literature was conducted, followed by discussions among experts to draft and evaluate a list of recommendations for managing knee OA non-pharmacologically.
- - Five key principles were established, emphasizing a combination of treatments, personalized management, adherence, appropriate exercise, and education, alongside specific recommendations for 11 modalities like braces, physical therapy, and weight loss.