Vaccine-induced T cell responses control Orthoflavivirus challenge infection without neutralizing antibodies in humans.

T cells have been identified as correlates of protection in viral infections. However, the level of vaccine-induced T cells needed and the extent to which they alone can control acute viral infection in humans remain uncertain. Here we conducted a double-blind, randomized controlled trial involving vaccination and challenge in 33 adult human volunteers, using the live-attenuated yellow fever (YF17D) and chimeric Japanese encephalitis-YF17D (JE/YF17D) vaccines.

Unmasking Subglottic Stenosis in an Asthmatic Emergency Needing Front-of-Neck Access: A Case Report.

Subglottic stenosis poses a rare but life-threatening risk for difficult tracheal intubation. Here, we report a unique case of undiagnosed subglottic stenosis discovered during emergency intubation of an 80-year-old woman with type 2 respiratory failure from infective exacerbation of asthma. A small calibre size 5.

Moral conviction interacts with metacognitive ability in modulating neural activity during sociopolitical decision-making.

The extent to which a belief is rooted in one's sense of morality has significant societal implications. While moral conviction can inspire positive collective action, it can also prompt dogmatism, intolerance, and societal divisions. Research in social psychology has documented the functional characteristics of moral conviction and shows that poor metacognition exacerbates its negative outcomes.

Unusual salt effects on the time-dependent behavior of charge and shape anisotropic hectorite clay gels: Role of electric double layer (EDL) repulsive force.

Salt strengthened the bond formed and quickened the bonding process of 3-5 wt. % hectorite gels during the structural rejuvenation process. This even occurred at 0.

Ecological risks of sulfonamides and quinolones degradation intermediates: Toxicity, microbial community, and antibiotic resistance genes.

The ecological risks posed by incompletely degraded antibiotic intermediates in aquatic environments warrant significant attention. This study investigated the degradation mechanisms of sulfonamides (sulfadiazine, sulfamethoxazole) and quinolones (ciprofloxacin, norfloxacin) during thermally activated persulfate (TAP) treatment. The main degradation mechanisms for sulfonamides involved S-N bond cleavage and -NH oxidation mediated by sulfate and hydroxyl radicals, whereas quinolone degradation occurred primarily through piperazine ring cleavage facilitated by a single linear oxygen.