Progesterone level in assisted reproductive technology: a systematic review and meta-analysis.

Elevated progesterone (EP) or inadequate progesterone levels during ART cycle monitoring may lead to cycle cancellations or further progesterone supplementation, but practice varies. It remains controversial whether modifying clinical practice in the presence or absence of EP improves clinical outcomes. This systematic review aims to investigate if progesterone levels at different phases of fresh and frozen ART cycles influence pregnancy outcomes, in particular, that pertaining to day 3 versus day 5 embryo transfers.

Gremlin-2 is a novel tumor suppressor that negatively regulates ID1 in breast cancer.

Background: Breast cancer is one of the most common cancers in women and is closely associated with obesity. Gremlin-2 (GREM2), an antagonist for bone morphogenetic proteins (BMPs), has been considered an inhibitor of adipogenic differentiation in adipose-derived stromal/stem cells. However, the role of GREM2 in breast cancer cells remains largely unknown, and its signaling mechanism has yet to be clarified.

Alterations in functional connectivity in the salience network shared by depressive symptoms and smartphone overuse.

Globally, the age when children start using smartphones has decreased. Concurrently, the increased use of smartphones among children in developmental stages has caused serious effects, such as depression. While neuroimaging studies have predicted a significant overlap between the neurobiological changes caused by depression and smartphone overuse, few have simultaneously examined them.