Genomic characterization of Escherichia coli with a polyketide synthase (pks) island isolated from ulcerative colitis patients.

The E. coli strains harboring the polyketide synthase (pks) island encode the genotoxin colibactin, a secondary metabolite reported to have severe implications for human health and for the progression of colorectal cancer. The present study involves whole-genome-wide comparison and phylogenetic analysis of pks harboring E.

Regulation of mutant huntingtin mitochondrial toxicity by phosphomimetic mutations within its N-terminal region.

Huntington's disease (HD), a neurodegenerative disease, affects approximately 30,000 people in the United States, with 200,000 more at risk. Mitochondrial dysfunction caused by mutant huntingtin (mHTT) drives early HD pathophysiology. mHTT binds the translocase of mitochondrial inner membrane (TIM23) complex, inhibiting mitochondrial protein import and altering the mitochondrial proteome.

Impact of Metabolic Health and Its Changes on Erosive Esophagitis Remission: A Cohort Study.

Background/aims: We aim to compare the remission of erosive esophagitis (EE) among individuals with different phenotypes based on their metabolic health and obesity status and investigate the impact of changes in metabolic health on the EE remission.

Methods: Asymptomatic adults (n = 16 845) with EE at baseline, who underwent follow-up esophagogastroduodenoscopy (EGD) were categorized into 4 groups as follows: metabolically healthy (MH) nonobese, metabolically unhealthy (MU) nonobese, MH obese, and MU obese. EE was defined as grade A or higher mucosal breaks observed using esophagogastroduodenoscopy.

Cellulose nanofiber-created air barrier enabling closed-cell foams prepared via oven-drying.

Cellulose foams are renewable and biodegradable materials that are promising substitutes for plastic foams. However, the scale-up fabrication of cellulose foams is severely hindered by technological complexity and cost- and time-consuming drying processes. Here, we developed a facile and robust method to fabricate cellulose foams via oven-drying following surfactant-assisted mechanical foaming of cellulose nanofibers (CNFs).

Development of a rapid enzymatic quantification method for hyaluronic acid based on the gene-mining of hyaluronate lyase.

Hyaluronic acid (HA), a vital polysaccharide naturally present in human tissues, is widely utilized in the food, pharmaceutical and cosmetic industries due to its diverse functionalities and bioactivity. Rapid and accurate quantification of HA is essential for the quality control of its products. Enzymatic quantification methods, known for their simplicity and high specificity, were employed for polysaccharide measurement.