Effect of butyric short-chain fatty acids on the bioelectric and contractile activity of gastrointestinal smooth muscle tissues.

The present study was undertaken to investigate the effect of butyric (C4) short-chain fatty acids on the bioelectric and contractile activity of smooth muscle (SM) tissues from rat and guinea-pig gastrointestinal tracts. The study was conducted in vitro on isolated SM preparations of rat gastric corpus and guinea pig taenia coli. The following methods were used: 1.

The effect of octanoic fatty acid on the cardiovascular system of the guinea pig.

The aim of the study was to clarify the role of octanoic acid (OA) in the development of cardiovascular disorders occurring in some liver diseases associated with high OA levels in blood serum. The effect of OA (caprylic acid) on the functional state of the cardiovascular system was studied in guinea pig by means of the thermodilution method and ultrasound Doppler echography. It was found that, as a result of its inotropic action, OA decreases arterial pressure and vascular resistance while increasing cardiac output.

The impact of butyric acid on the cardiovascular system.

The influence of sodium salt of butyric acid (C4H7NaO2) on the functional state of the cardiovascular system was studied on 12 guinea-pigs and 15 rabbits by the thermodilution method. The following parameters were determined: cardiac output (CO), arterial blood pressure (AP), total peripheral vascular resistance (TPVR), and in rabbits the heart rate (HR). It was found that butyric acid induces significant changes in TPVR, which correlate with changes in CO and AP.