Disruption of RNA-binding proteins in neurological disorders.

RNA-binding proteins (RBPs) are multifunctional proteins essential for the regulation of RNA processing and metabolism, contributing to the maintenance of cell homeostasis by modulating the expression of target genes. Many RBPs have been associated with neuron-specific processes vital for neuronal development and survival. RBP dysfunction may result in aberrations in RNA processing, which subsequently initiate a cascade of effects.

Mixed-effects neural network modelling to predict longitudinal trends in fasting plasma glucose.

Background: Accurate fasting plasma glucose (FPG) trend prediction is important for management and treatment of patients with type 2 diabetes mellitus (T2DM), a globally prevalent chronic disease. (Generalised) linear mixed-effects (LME) models and machine learning (ML) are commonly used to analyse longitudinal data; however, the former is insufficient for dealing with complex, nonlinear data, whereas with the latter, random effects are ignored. The aim of this study was to develop LME, back propagation neural network (BPNN), and mixed-effects NN models that combine the 2 to predict FPG levels.

Mutation on JmjC domain of UTX impaired its antitumor effects in pancreatic cancer via inhibiting G0S2 expression and activating the Toll-like signaling pathway.

Background: Recently, the incidence of pancreatic cancer (PC) has gradually increased. Research has shown that UTX mutants are critical in tumors. However, the underlying mechanisms remain incompletely understood.

Late onset of biliobronchial fistula - a serious complication of hemihepatectomy for atrophic liver with hepatolithiasis: a case report and review of the literature.

Background: Acquired bronchobiliary fistula (BBF) is a rare but life-threatening complication that can occur as a result of oncological processes, inflammatory reactions, parasite infections, thoracoabdominal trauma, or invasive procedures associated with iatrogenic injury. However, the potential etiology of BBF caused by instrumental issues when using ultrasonic scalpels resulting in diathermy burn and its post-burn effects has never been reported.

Case Presentation: Herein, we present a case of a 65-year-old woman who developed BBF one month after hepatectomy and presented with refractory irritating cough accompanied by yellow bitter sputum.