Publications by authors named "Y Loe-Mie"
Article Synopsis
- Phylogenetic research has grouped previously isolated groups like nematodermatids, acoels, and xenoturbelids into a new phylum called Xenacoelomorpha.
- Some studies suggest that Xenacoelomorpha may be closely related to Ambulacraria, while others indicate it could be a sibling group to all Bilateria.
- Research using single-cell RNA sequencing in the marine worm Xenoturbella bocki reveals similarities in nerve nets, muscles, and glands that support the idea of shared evolutionary traits among various animal groups, reinforcing the monophyly of Xenacoelomorpha.
Article Synopsis
- Schizophrenia (SZ) is a complex mental disorder influenced by genetics, and researchers analyzed a large set of genomic data to identify dysfunctional brain networks related to the condition.
- They identified three overlapping subclusters linked to microtubule function, the actin cytoskeleton, and synaptic transmission, and examined de novo mutations in SZ patients from Algeria, France, and Japan.
- The study found specific mutations associated with protein functions crucial for the cytoskeleton and transport, and animal experiments indicated that one gene variant led to brain structure issues, suggesting avenues for future therapeutic research.
Anti-CD19 chimeric antigen receptor (CAR) T cell therapy represents a breakthrough for the treatment of B cell malignancies. Yet, it can lead to severe adverse events, including cytokine release syndrome (CRS), which may require urgent clinical management. Whether interpatient variability in CAR T cell subsets contributes to CRS is unclear.
View Article and Find Full Text PDFRecent advances in synthetic embryology have opened new avenues for understanding the complex events controlling mammalian peri-implantation development. Here, we show that mouse embryonic stem cells (ESCs) solely exposed to chemical inhibition of SUMOylation generate embryo-like structures comprising anterior neural and trunk-associated regions. HypoSUMOylation-instructed ESCs give rise to spheroids that self-organize into gastrulating structures containing cell types spatially and functionally related to embryonic and extraembryonic compartments.
View Article and Find Full Text PDFThe coordinated differentiation of progenitor cells into specialized cell types and their spatial organization into distinct domains is central to embryogenesis. Here, we developed and applied an unbiased spatially resolved single-cell transcriptomics method to identify the genetic programs underlying the emergence of specialized cell types during mouse limb development and their spatial integration. We identify multiple transcription factors whose expression patterns are predominantly associated with cell type specification or spatial position, suggesting two parallel yet highly interconnected regulatory systems.
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