Survival analysis of time to cure on multi-drug resistance tuberculosis patients in Amhara region, Ethiopia.

Background: Multidrug-resistant tuberculosis (MDR-TB) is caused by bacteria that are resistant to the most effective anti-tuberculosis drug. The MDR-TB is an increasing global problem and the spread of MDR-TB has different recovery time for different patients. Therefore, this study aimed to investigate the recovery time of MDR-TB patients in Amhara region, Ethiopia.

Chloramphenicol-resistant Salmonella typhi from a patient in Addis Abeba.

The clinical history and treatment outcome of a twenty-year old female patient (EN) with typhoid fever is presented. Laboratory examination showed that the etiological agent was a strain of Salmonella typhi which was simultaneously resistant to chloramphenicol (C), streptomycin (S), sulphonamides (Su) and tetracycline (T). Genetic and molecular analysis of this strain demonstrated that resistance to CSSuT was encoded in a plasmid which showed a thermosensitive (28 degrees C) transfer to an Escherichia coli K12 recipient, at a frequency of 4.