Publications by authors named "Y Le Manach"
Background: Consensus recommendations regarding the threshold levels of cardiac troponin elevations for the definition of perioperative myocardial infarction and clinically important periprocedural myocardial injury in patients undergoing cardiac surgery range widely (from >10 times to ≥70 times the upper reference limit for the assay). Limited evidence is available to support these recommendations.
Methods: We undertook an international prospective cohort study involving patients 18 years of age or older who underwent cardiac surgery.
Article Synopsis
- The PVC-RAM trial aims to assess whether virtual care with remote automated monitoring (RAM) improves post-discharge outcomes for patients who have undergone nonelective surgeries during the COVID-19 pandemic.
- The study involves 900 adults from 8 Canadian hospitals, who are randomly assigned to receive either RAM or standard care, with daily monitoring of vital signs and interaction with nurses over a 30-day period.
- Results from this trial will help shape better post-surgical care strategies and will be shared through various platforms for broader impact, both during and after the pandemic.
Interest in developing and using novel biomarkers in critical care and perioperative medicine is increasing. Biomarkers studies are often presented with flaws in the statistical analysis that preclude them from providing a scientifically valid and clinically relevant message for clinicians. To improve scientific rigor, the proper application and reporting of traditional and emerging statistical methods (e.
View Article and Find Full Text PDFBackground: We aimed to establish diagnostic criteria for bleeding independently associated with mortality after noncardiac surgery (BIMS) defined as bleeding during or within 30 days after noncardiac surgery that is independently associated with mortality within 30 days of surgery, and to estimate the proportion of 30-day postoperative mortality potentially attributable to BIMS.
Methods: This was a prospective cohort study of participants ≥45 yr old having inpatient noncardiac surgery at 12 academic hospitals in eight countries between 2007 and 2011. Cox proportional hazards models evaluated the adjusted relationship between candidate diagnostic criteria for BIMS and all-cause mortality within 30 days of surgery.