Tracking Topological and Electronic Effects on the Folding and Stability of Guanine-Deficient RNA G-Quadruplexes, Engineered with a New Computational Tool for De Novo Quadruplex Folding.

The initial aim of this work was to elucidate the mutual influence of different single-stranded segments (loops and caps) on the thermodynamic stability of RNA G-quadruplexes. To this end, we used a new NAB-GQ-builder software program, to construct dozens of two-tetrad G-quadruplex topologies, based on a designed library of sequences. Then, to probe the sequence-morphology-stability relationships of the designed topologies, we performed molecular dynamics simulations.

The place of anxiety in depressive symptomatology.

1 In the same sample of 42 depressed inpatients, treated by a sequence of anxiolytic followed by antidepressant, total depression, anxiety and retardation scores are compared. 2 Results confirm that retarded patients are good responders to antidepressants. Non-retarded patients do not respond to antidepressants but respond partially to anxiolytics.