Association between dietary carotenoid intake and vertebral fracture in people aged 50 years and older: a study based on the National Health and Nutrition Examination Survey.

Unlabelled: This study discussed the association between dietary intake of carotenoids and vertebral fractures by analyzing the target data, concluding a result of negative association and providing valuable information on vertebral fracture.

Objective: This study is to explore the association between dietary intake of carotenoids and vertebral fractures.

Methods: Data of individuals aged ≥ 50 years from the 2013-2014 National Health and Nutrition Examination Survey (NHANES) database were used in this cross-sectional study.

SARM1 deletion inhibits astrogliosis and BBB damage through Jagged-1/Notch-1/NF-κB signaling to improve neurological function after ischemic stroke.

Reactive astrogliosis is a critical process in the development of ischemic stroke. However, the precise mechanism by which reactive astrogliosis changes the pathogenesis of ischemic stroke remains elusive. Sterile alpha and TIR motif-containing 1 protein (SARM1) plays a key role in axonal degeneration and is involved in different cell death programs that regulate neuronal survival.

Neurodegenerative diseases: Epigenetic regulatory mechanisms and therapeutic potential.

Neurodegenerative diseases (NDDs) are a class of diseases in which the progressive loss of subtype-specific neurons leads to dysfunction. NDDs include Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), and amyotrophic lateral sclerosis (ALS), among others. Previous studies have demonstrated that the pathogenesis of NDDs involves various mechanisms, including genetic factors, oxidative stress, apoptosis, and the immune response.

PGRN knockdown alleviates pulmonary fibrosis regulating the Akt/GSK3β signaling pathway.

Background: Pulmonary fibrosis (PF) is a serious, chronic, and progressive disease with increased collagen deposition and the collapse of lung structures. Currently, the antifibrotic drugs for PF treatment, nintedanib and pirfenidone, have been proven to reduce the decline of pulmonary function in PF, but both have side effects, and to date, there is no significantly effective treatment to halt the progression of PF. The aim of this study was to investigate the molecular mechanism of pregranuloprotein (PGRN) in pulmonary fibrosis through in vitro and in vivo experiments.

Association of a 7.9 kb Endogenous Retrovirus Insertion in Intron 1 of CD36 with Obesity and Fat Measurements in Sheep.

Background: Endogenous retroviruses (ERVs) enhance genetic diversity in vertebrates, including sheep. This study investigates the role of Ov-ERV-R13-CD36 within CD36 gene and its association with phenotypic traits in sheep. Analyzing 58 sheep genomes revealed that ERVs constitute approximately 6.