Publications by authors named "Y L Skorodok"
Background: Differential diagnosis of hypogonadotropic hypogonadism (HH) and constitutional delay of puberty (CDP) is extremely important since with the latter puberty begins and completes without any medical intervention and in the case of HH puberty does not occur or is incomplete. Failure to start treatment on time leads to medical and psychosocial maladjustment of the patient.
Aim: Development of a method for differential diagnosis of hypogonadotropic hypogonadism and constitutional delay of puberty in boys 13.
Article Synopsis
- Somatrogon, a long-acting human growth hormone, is tested as a weekly treatment for children with growth hormone deficiency in a 12-month study compared to daily GH (Genotropin).
- The study involved 53 prepubertal children, who were divided into groups receiving different doses of somatrogon or Genotropin, and many continued in a long-term safety and efficacy evaluation.
- Results showed significant improvements in annual height velocity and height standard deviation scores over the treatment period, with most side effects being mild and unrelated to the medication.
Context: TransCon Growth Hormone (GH) (Ascendis Pharma) is a long-acting recombinant sustained-release human GH prodrug in development for children with GH deficiency (GHD).
Objective: To compare the pharmacokinetics, pharmacodynamics, safety, and efficacy of weekly TransCon GH to that of daily GH in prepubertal children with GHD.
Design: Randomized, open-label, active-controlled study of three doses of weekly TransCon GH versus daily Genotropin (Pfizer).