Interplay of natural and anthropogenic inputs on the groundwater contamination of Beenaganj-Chachura block.

The present research work investigates the impact of natural and anthropogenic inputs on the chemistry and quality of the groundwater in the Beenaganj-Chachura block of Madhya Pradesh, India. A total of 50 groundwater samples were examined for nitrates, fluoride, chlorides, total dissolved solids, calcium, magnesium, pH, total hardness, and conductivity, and their impact on entropy-weighted water quality index and pollution index of groundwater (PIG) was investigated via the response surface methodology (RSM) using the central composite design. According to analytical findings, Ca, Mg, Cl, SO, and NO exceed the desired limit and permitted limit set by the Bureau of Indian Standards (BIS) and the World Health Organization (WHO).

Co-infection of SARS-CoV-2 with human coronavirus OC43 in a patient with underlying lung disease: A case report.

Co-infections with SARS-CoV-2 remain relatively rare and there is limited published data on the consequences of these events. We present the case of a 26-year-old man with SARS-CoV-2 and human coronavirus OC43 who had a severe infection resulting in prolonged hospitalization. Consideration of co-infections should be considered in high-risk patients.

Development of deforestation and land cover database for Bhutan (1930-2014).

Bhutan is a mountainous country located in the Himalayan biodiversity hotspot. This study has quantified the total area under land cover types, estimated the rate of forest cover change, analyzed the changes across forest types, and modeled forest cover change hotpots in Bhutan. The topographical maps and satellite remote sensing images were analyzed to get the spatial patterns of forest and associated land cover changes over the past eight decades (1930-1977-1987-1995-2005-2014).

A look at the potential association between PICOT framing of a research question and the quality of reporting of analgesia RCTs.

Background: Methodologists have proposed the formation of a good research question to initiate the process of developing a research protocol that will guide the design, conduct and analysis of randomized controlled trials (RCTs), and help improve the quality of reporting such studies. Five constituents of a good research question based on the PICOT framing include: Population, Intervention, Comparator, Outcome, and Time-frame of outcome assessment. The aim of this study was to analyze if the presence a structured research question, in PICOT format, in RCTs used within a 2010 meta-analysis investigating the effectiveness of femoral nerve blocks after total knee arthroplasty, is independently associated with improved quality of reporting.

Synthesis of privileged scaffolds by using diversity-oriented synthesis.

An elegant reagent-controlled strategy has been developed for the generation of a diverse range of biologically active scaffolds from a chiral bicyclic lactam. Reduction of the chiral lactam with LAH or alkylation with LHMDS to trigger different cyclization reactions have been shown to generate privileged scaffolds, such as pyrrolidines, indolines, and cyclotryptamines. Their amenability to substitution allows us to create various compound libraries by using these scaffolds.