Clinical characteristics of anti-myelin oligodendrocyte glycoprotein antibody among aquaporin-4 negative neuromyelitis optica spectrum disorders in Egyptian patients.

Some patients with neuromyelitis optica spectrum disorder (NMOSD)-like symptoms test negative for anti-aquaporin-4 (anti-AQP4) antibodies. Among them, a subset has antibodies targeting myelin oligodendrocyte glycoprotein (MOG), a condition now termed MOG antibody-associated disease (MOGAD). MOGAD shares features with NMOSD, like optic neuritis and myelitis, but differs in pathophysiology, clinical presentation, imaging findings, and biomarkers.

Bilateral Fuchs' Superficial Marginal Keratitis Diagnosis and Treatment.

In this study, we reported two patients with clinical pictures compatible with the diagnosis of bilateral Fuchs' superficial marginal keratitis (FSMK) treated with surgical treatment and anti-inflammatory drugs. The cases suffered from bilateral photophopia, blurred vision, and pseudopterygium with normal intraocular pressure (IOP). Pseudopterygia extended from temporal and nasal sides and had a gray line between the corneal normal epithelium with no lipid deposits.

Structure-Activity Relationship Studies in a Series of 2-Aryloxy--(pyrimidin-5-yl)acetamide Inhibitors of SLACK Potassium Channels.

Epilepsy of infancy with migrating focal seizures (EIMFS) is a rare, serious, and pharmacoresistant epileptic disorder often linked to gain-of-function mutations in the gene. encodes the sodium-activated potassium channel known as SLACK, making small molecule inhibitors of SLACK channels a compelling approach to the treatment of EIMFS and other epilepsies associated with mutations. In this manuscript, we describe a hit optimization effort executed within a series of 2-aryloxy--(pyrimidin-5-yl)acetamides that were identified via a high-throughput screen.

Case Report: Bilateral Spigelian Hernia With Meckel's diverticulum.

Spigelian hernia is an uncommon form of ventral hernia, with an incidence ranging from 0.1% to 2%. This case report describes a 72-year-old female who presented with an obstructed right Spigelian hernia, a left Spigelian hernia, and an uncomplicated Meckel's diverticulum, along with the management approach.

Tumor mimicking cervicocranial actinomycosis with intracranial extension- a diagnosic dillema-first case report in somalia.

Actinomycosis is a rare bacterial infection characterized by nonspecific clinical and radiological manifestations. It often presents in cervicofacial, abdominopelvic, and thoracopulmonary forms, with cervicofacial being the most common. The extensive differential diagnosis and vague clinical and radiological features contribute to diagnostic challenges.