Rnd3 protects against doxorubicin-induced cardiotoxicity through inhibition of PANoptosis in a Rock1/Drp1/mitochondrial fission-dependent manner.

Doxorubicin, a representative drug of the anthracycline class, is widely used in cancer treatment. However, Doxorubicin-induced cardiotoxicity (DIC) presents a significant challenge in its clinical application. Mitochondrial dysfunction plays a central role in DIC, primarily through disrupting mitochondrial dynamics.

Ancient engineers: The role of plateau pika in shaping ecological uniqueness and guiding plant diversity conservation in alpine grasslands.

Small burrowing herbivores play a crucial role in maintaining structure and function of grassland ecosystems. To date, our understanding of whether practicing ecological uniqueness can enhance plant diversity conservation under small herbivore disturbances remains limited. Here, we investigate the ecological uniqueness of plant communities, which include habitats disturbed and undisturbed by plateau pikas.

Online health information seeking behavior among breast cancer patients and survivors: a scoping review.

Purpose: This scoping review aims to summarize online health information seeking (OHIS) behavior among breast cancer patients and survivors, identify research gaps, and offer insights for future studies.

Methods: Following Arksey and O'Malley's framework, we conducted a review across PubMed, Web of Science, CINAHL, MEDLINE, Cochrane, Embase, CNKI, Wanfang Data, and SinoMed, covering literature from 1 January 2014 to 13 August 2023. A total of 1,368 articles were identified, with 33 meeting the inclusion criteria.

Systematic functional characterization of non-coding regulatory SNPs associated with central obesity.

Central obesity is associated with higher risk of developing a wide range of diseases independent of overall obesity. Genome-wide association studies (GWASs) have identified more than 300 susceptibility loci associated with central obesity. However, the functional understanding of these loci is limited by the fact that most loci are in non-coding regions.

All-in-one: Harnessing multifunctional natural polysaccharide spray hydrogel loaded with polyphenol-metal nanoparticles for fruit preservation.

Fruit preservation materials play an instrumental role in preventing fruit deterioration and extending shelf life. However, existing fresh-keeping materials often prove inadequate in simultaneously achieving antibacterial properties, maintaining freshness, antioxidant effects, good biocompatibility, and prolonged fruit shelf life. Therefore, we present the first preparation of a natural polysaccharide spray hydrogel (Q/O/Zn hydrogel), loaded with chlorogenic acid‑zinc nanoparticles (CA@ZnNPs), utilizing quaternary ammonium insect chitosan (QECS) and oxidized pullulan (OPUL) for the preservation of perishable fruits.