Morusin Reverses Epithelial-Mesenchymal Transition in Gallbladder Cancer Cells by Regulating STAT3/HIF-1α Signaling.

Gallbladder cancer is the most prevalent malignancy of the biliary tract and has a dismal overall survival even in the present day. The development of new drugs holds promise for improving the prognosis of this lethal disease. The possible anti-neoplastic role of morusin was investigated both in vitro and in vivo.

Effective pretreatment of tea stem via poly-deep eutectic solvent for promoting platform molecule production and obtaining fluorescent lignin.

In this study, polyethylene glycol 200 (PEG200) was employed as hydrogen bond acceptor, while organic acids served as hydrogen bond donors, to formulate poly-deep eutectic solvents (PDESs), which were utilized to pretreat tea stem. Specially, combining PEG200 and oxalic acid (OA) exhibited a notably high cellulose retention (82.03 %) and most efficient hemicellulose (97.

Synergistic development of intangible cultural heritage and tourism industry: Empirical experiences from Jilin, China.

This study focuses on the Jilin region of China, conducting a multidimensional assessment of the current state of the synergistic development between Intangible Cultural Heritage (ICH) and the tourism industry in the area. The objective is to explore the issues surrounding the coordinated development of ICH and the tourism sector. The findings are as follows: 1) The overall coupling degree between the ICH and tourism systems in the Jilin region is 0.

Low serum serotonin is associated with functional decline, mild behavioural impairment and brain atrophy in dementia-free subjects.

Brain serotonin dysregulation is associated with dementia and neuropsychiatric symptomology. However, the prognostic utility of circulating serotonin levels in detecting features of prodromal dementia including functional decline, cognitive impairment, mild behavioural impairment and brain atrophy remains unclear. In this prospective study of memory clinic subjects followed-up for ≤5 years, dementia-free subjects, classified as having no cognitive impairment or cognitive impairment, no dementia at baseline, underwent annual neuropsychological assessments including Montreal Cognitive Assessment, Global Cognition scores and Clinical Dementia Rating Scale Global Scores (where a ≥ 0.

A Phase-Transition-Free Sodium Vanadium Phosphate Cathode via Medium-Entropy Engineering for Superior Sodium Ion Batteries.

NaV(PO), based on multi-electron reactions between V/V/V, is a promising cathode material for SIBs. However, its practical application is hampered by the inferior conductivity, large barrier of V/V, and stepwise phase transition. Herein, these issues are addressed by constructing a medium-entropy material (NaVTiAlCrMnNi(PO), ME-NVP) with strong ME─O bond and highly occupied Na2 sites.