Chromosomal rearrangements associated with SMC5/6 deficiency in DNA replication.

Completion of DNA replication before chromosome segregation is essential for the stable maintenance of the genome. Under replication stress, DNA synthesis may persist beyond S phase, especially in genomic regions that are difficult to proceed with the replication processes. Incomplete replication in mitosis emerges as non-disjoined segment in mitotic chromosomes leading to anaphase bridges.

Development of a Tumor Growth-responsive Robust Planning Method for Head and Neck Cancer in Carbon-ion Radiotherapy.

Background/aim: The current study aimed to evaluate a treatment planning method that is robust against tumor growth and to assess its effectiveness in particle therapy for head and neck cancer.

Patients And Methods: The proposed method optimizes dose distribution by replacing the relative stopping power ratio (rSPR) of the clinical target volume (CTV) cavity region with a tumor-equivalent rSPR (Condition 1). The optimized initial treatment plan template was then recalculated using in-room CT images acquired in the same treatment position, and the doses to the tumor and organs at risk were compared with those in the initial treatment plan.

Synthesis of ()-Enediynes via Stereoinvertive Nucleophilic Substitution of ()-Sulfonylethenes with Arylethynide, and Their Aggregation-Induced Optical Properties.

()-Enediynes were successfully synthesized from a trio of terminal ethynes through consecutive three-step reactions: iodosulfonylation of ethyne with I/PhSONa, followed by ethynylations of iodo and sulfonyl moieties of the resulting iodosulfonylethene via Sonogashira-Hagihara coupling and nucleophilic addition-elimination, respectively. The molecular structure of the obtained ()-enediyne was fully characterized by X-ray crystal structure analysis, revealing that the nucleophilic substitution of ()-sulfonylethene with arylethynide underwent a selective stereoinversion. The ()-enediynes exhibited photoluminescence in both the solution and solid states (crystals and powders).

Roll-to-Roll SiOx Synthesis on Polyethylene Terephthalate Film by Atmospheric-Pressure Plasma-Assisted Chemical Vapor Deposition.

Silicon oxide (SiOx) coatings are attracting significant attention and are widely used in industrial applications. They can be prepared by plasma-assisted chemical vapor deposition (PACVD). PACVD at atmospheric pressure (AP-PACVD) is often employed to synthesize SiOx coatings, but it has generally not been scaled up to an industrially viable level.