Publications by authors named "Y Kura"
Gut microbiota plays a crucial role in the development and progression of prostate cancer, with previous studies indicating that certain bacterial taxa are more abundant in castration-resistant prostate cancer (CRPC) compared to hormone-sensitive prostate cancer (HSPC). Notably, the composition of gut microbiota can vary significantly by geographic region, and Japanese individuals have a distinct microbial profile. However, research exploring these differences within Japanese populations remains limited.
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- A 60-year-old man suffered from two months of fever and a month of skin rash, prompting further medical evaluation due to significant clinical symptoms like weight loss and night sweats.
- Imaging studies revealed a mass in his left lung and swelling in the liver and spleen, leading to a suspicion of lung cancer or malignant lymphoma.
- A liver biopsy confirmed B-cell lymphoma, and after chemotherapy, follow-up imaging showed mixed results—some issues resolved while others remained—ultimately revealing a diagnosis of small-cell lung carcinoma in addition to the lymphoma, which improved his prognosis with treatment.
Background: Genome DNA methylation profiling is a promising yet costly method for cancer classification, involving substantial data. We developed an ensemble learning model to identify cancer types using methylation profiles from a limited number of CpG sites.
Methods: Analyzing methylation data from 890 samples across 10 cancer types from the TCGA database, we utilized ANOVA and Gain Ratio to select the most significant CpG sites, then employed Gradient Boosting to reduce these to just 100 sites.
Chronic systemic inflammation caused by diseases such as ulcerative colitis (UC) and Crohn's disease (CD) increases the risk of developing colorectal cancer (CRC). Recent evidence indicates that patients with UC are more susceptible to prostate cancer (PCa), and individuals with PCa may also be at a higher risk of developing CRC. However, these relationships are not well defined.
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- Prostate cancer development is influenced by lifestyle factors and gut microbiome changes, with a specific link to gut dysbiosis, but the exact mechanisms are still unclear.
- The study analyzed stool samples from tumor-bearing mice and humans to investigate the relationship between gut microbes and prostate cancer status, identifying key bacterial taxa associated with the disease.
- Results indicate that both humans and mice show distinct gut microbiome profiles related to prostate cancer, highlighting potential bacterial metabolites that may promote the disease and suggesting a preclinical model for further research.