Publications by authors named "Y Kugai"
The study introduces a novel C-symmetric β-diketone compound, BTA-D3, and its monomeric counterpart, D, with a focus on their synthetic procedure, photophysical properties and aggregation behavior. Both compounds exhibit characteristic absorption and weak fluorescence in solution, with BTA-D3 displaying higher absorption coefficients due to its larger number of diketone units. Density Functional Theory (DFT) calculations suggest increased co-planarity of diketone groups in BTA-D3.
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- Photoinduced tuning of aromaticity is gaining attention for its potential in creating new photochromic materials, particularly those based on diaryl[5]helicene molecular switches.
- Among the studied compounds, two derivatives (2 a and 3 a) exhibited reversible photochromism and fluorescence photoswitching, while another (1 a) did not show any photochromic reaction.
- The study highlights how changes in aromaticity and lower activation energy in diarylethene switches can enhance thermal bleaching rates, paving the way for advancements in fluorescence switching technologies.
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- A 72-year-old woman with advanced gastric cancer was treated with a chemotherapy regimen including TS-1 and CDDP.
- After the first round of treatment, she showed a partial response, leading to surgery for total gastrectomy.
- Post-surgery, pathology revealed no cancer cells in the stomach and only a few lymph node metastases, and she has remained cancer-free for nearly 2 years.
Protein-losing gastroenteropathy (PLG) can occur as a manifestation of various diseases including autoimmune disorders, and optimal therapy of these underlying diseases may be the only effective remedy for PLG. In the present report, we describe a case of a 54-year-old woman with PLG associated with an autoimmune disease, presumably CREST syndrome. She failed to respond to steroid treatment.
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