Publications by authors named "Y Kibe"
Article Synopsis
- Mutations in the IDH gene are crucial for the development of astrocytoma and oligodendroglioma, but their role in tumor maintenance and aggressive transformation is still unclear.
- Researchers observed an unusual case of IDH-mutant astrocytoma that transformed into two distinct types: one with IDH mutations and another without, showing differing characteristics in aggression.
- The IDH-wild-type component lacked the IDH mutation due to chromosome loss, and also acquired additional genetic changes, indicating that these tumors may become independent of IDH mutations and develop resistance to treatments targeting those mutations.
Li-Fraumeni syndrome (LFS) is an autosomal dominant tumor predisposition syndrome caused by heterozygous germline mutations or deletions in the TP53 tumor suppressor gene. Central nervous system tumors, such as choroid plexus tumors, medulloblastomas, and diffuse gliomas, are frequently found in patients with LFS. Although molecular profiles of diffuse gliomas that develop in pediatric patients with LFS have been elucidated, those in adults are limited.
View Article and Find Full Text PDFPatients with diffuse frontal gliomas often present with post-operative apathy after tumour removal. However, the association between apathy and tumour removal of gliomas from the frontal lobe remains unknown. This study aimed to investigate the factors influencing post-operative apathy after tumour removal in patients with diffuse frontal gliomas.
View Article and Find Full Text PDFOncogene-induced DNA replication stress (RS) and consequent pathogenic R-loop formation are known to impede S phase progression. Nonetheless, cancer cells continuously proliferate under such high-stressed conditions through incompletely understood mechanisms. Here, we report taurine upregulated gene 1 (TUG1) long noncoding RNA (lncRNA), which is highly expressed in many types of cancers, as an important regulator of intrinsic R-loop in cancer cells.
View Article and Find Full Text PDFPurpose: Local control (LC) is an important outcome of local cancer therapy, besides overall survival (OS). We conducted a comprehensive literature search to investigate whether a high LC rate contributes to good OS in radiotherapy for early-stage non-small cell lung cancer (ES-NSCLC).
Materials And Methods: Studies in patients receiving radiotherapy for peripheral ES-NSCLC, mainly staged as T1-2N0M0 were included for a systematic review.