Publications by authors named "Y Katsuki"
We investigated the effects of individual and cumulative cerebral small vessel disease (SVD) markers on long-term clinical outcomes in spontaneous intracerebral hemorrhage (sICH) patients. This prospective, single-center cohort study was conducted from 2012 to 2019. SVD markers, including lacunae, cerebral microbleeds, white matter hyperintensity (WMH), and perivascular spaces in the basal ganglia, were assessed to calculate a summary SVD score.
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- - Fanconi anemia (FA) is a genetic disorder that hinders the body’s ability to fix DNA damage, leading to issues like bone marrow failure and increased leukemia risk due to the impact on blood stem cells.
- - Research suggests that the protein SLFN11 influences how cells respond to DNA damage and affects the effectiveness of cancer chemotherapy, particularly in the context of the hematopoietic (blood-forming) system where SLFN11 is highly expressed.
- - Findings indicate that reducing SLFN11 expression in FA cells decreases their sensitivity to DNA damage, and SLFN11 destabilizes new DNA strands when replication processes are interrupted, highlighting its significant role in FA's impact on replication stress response.
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- The study investigated the impact of seasonal changes on glycemic control in type 2 diabetes patients during the COVID-19 pandemic, focusing on data from Sugi Cardiovascular Hospital in late 2021.
- A total of 86 patients were analyzed, revealing significant seasonal variations in hemoglobin A1c (HbA1c) levels, particularly higher in spring and lower in autumn over the three years studied (2019-2021).
- Interestingly, despite the pandemic's restrictions, the seasonal trends in glycemic control remained consistent, with no patients contracting COVID-19 during the study period.
Background: Nivolumab combination chemotherapy has recently emerged as a potential first-line treatment for patients with unresectable or metastatic gastric cancer (GC). Further research has indicated that R0 resection by conversion surgery could be an effective treatment strategy to improve overall survival. However, there have been limited reports on the successful application of conversion surgery following combination chemotherapy achieving pathological complete response (pCR) in cases of advanced gastric remnant cancer with liver metastasis.
View Article and Find Full Text PDFThe Schlafen (SLFN)11 gene has been implicated in various biological processes such as suppression of HIV replication, replication stress response, and sensitization of cancer cells to chemotherapy. Due to the rapid diversification of the SLFN family members, it remains uncertain whether a direct ortholog of human SLFN11 exists in mice. Here we show that mSLFN8/9 and hSLFN11 were rapidly recruited to microlaser-irradiated DNA damage tracks.
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