Publications by authors named "Y Katono"
Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2012: General view of the pathogens' antibacterial susceptibility.
J Infect Chemother
September 2017
Article Synopsis
- A nationwide study in Japan in 2012 focused on monitoring the antibiotic resistance of bacterial pathogens responsible for respiratory infections in adult patients.
- A total of 1,236 bacterial strains were tested, revealing high resistance rates, including 51.3% methicillin-resistant Staphylococcus aureus and concerning levels of antibiotic resistance in other bacteria like Klebsiella pneumoniae and Pseudomonas aeruginosa.
- The findings highlight the importance of ongoing surveillance to understand and address the increasing resistance of bacterial respiratory pathogens to antimicrobial treatments.
Genetic variations in cytochrome P450 1A2 (CYP1A2) are associated with interindividual variability in the metabolism and efficacy of many medications. Twenty CYP1A2 variants harboring amino acid substitutions were analyzed for functional changes in enzymatic activity. Recombinant CYP1A2 variant proteins were heterologously expressed in COS-7 cells.
View Article and Find Full Text PDFGenetic variations in cytochrome P450 4A11 (CYP4A11) contributes to inter-individual variability in the metabolism of fatty acids such as arachidonic acid. CYP4A11 metabolizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), which is important for the regulation of blood pressure. Polymorphisms in CYP4A11 are associated with susceptibility to hypertension.
View Article and Find Full Text PDFThe development of an effective rat model of incisional surgical site infection (SSI) has so far proven difficult. In this study, we created a novel incisional SSI model and validated it in terms of both macroscopic and microscopic aspects including its response to treatment using antimicrobial wound-dressing, Aquacel Ag(®). Wounds were created on the dorsum of rats.
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