Publications by authors named "Y Katoh"
Primary cilia have specific proteins on their membrane to fulfill their sensory functions. Preservation of the specific protein composition of cilia relies on the barrier function of the transition zone (TZ) located at the ciliary base. Defects in cilia and the TZ cause ciliopathies, which have diverse clinical manifestations, including Meckel syndrome (MKS).
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- A study explored the effectiveness of the oral human papillomavirus (HPV) vaccine IGMKK16E7 in treating cervical intraepithelial neoplasia, showing promising results where some patients experienced a complete histological response.
- Researchers analyzed cervix-exfoliated cell samples from 42 patients to identify biomarkers that could predict the success of the vaccine, focusing on various gene expressions related to immune response.
- The key finding was that lower levels of the biomarker CD86 correlated with a higher likelihood of achieving a complete response to the vaccine, with CD86-low patients demonstrating a significantly increased response rate compared to those with higher CD86 levels.
Junctional epidermolysis bullosa is an intractable cutaneous disorder in humans causing skin fragility and blistering due to mutations in genes encoding essential molecules adhering epidermis and dermis including collagen XVII. However, the pathogenesis still remains to be not fully understood perhaps because of a lack of appropriate animal models. In this study, we report novel mutant rats experiencing junctional epidermolysis bullosa, which was confirmed to be caused by a frameshift mutation of Col17a1 gene, as a rat model for investigating the underlying mechanism of pathogenesis.
View Article and Find Full Text PDFDespite widespread cervical cancer (CC) screening programs, low participation has led to high morbidity and mortality rates, especially in developing countries. Because early-stage CC often has no symptoms, a non-invasive and convenient diagnostic method is needed to improve disease detection. In this study, we developed a new approach for differentiating both CC and cervical intraepithelial neoplasia (CIN)2/3, a precancerous lesion, from healthy individuals by exploring CC fatty acid metabolic reprogramming.
View Article and Find Full Text PDFBackground: No previous reports have characterized national profiles of soft-tissue sarcoma overall. We examined the nationwide statistics for soft-tissue sarcoma in Japan using data from the population-based National Cancer Registry.
Methods: We identified 23 522 soft-tissue-sarcoma patients who were entered in the National Cancer Registry during 2016-19 using International Classification of Diseases-Oncology, Third Edition codes for cancer topography and morphology.