Synthesis and evaluation of isoxazole derivatives as lysophosphatidic acid (LPA) antagonists.

A series of isoxazole derivatives were synthesized and their antagonistic activities against LPA stimulation on both LPA(1)/CHO cells and rHSC cells were evaluated. Among them, 3-(4-[4-[1-(2-chloro-cyclopent-1-enyl)-ethoxycarbonylamino]-isoxazol-3- y]]-benzylsulfanyl)-propionic acid (34) showed the most potent activities.

[A case of gastric cancer with a synchronous hepatic metastasis responding to postoperative oral administration of UFT and intermittent intrahepatic arterial chemotherapy of 5-FU].

A 65-year-old male was admitted to our hospital because of sudden onset of upper abdominal pain due to the perforation of gastric cancer with synchronous hepatic metastasis. He underwent total gastrectomy with lymphatic dissection of D1 + alpha. Pathological diagnosis of the surgical specimen was moderately differentiated tubular adenocarcinoma.

Aspiration biopsy cytology of secretory carcinoma of the breast. A case report.

Secretory carcinoma diagnosed by aspiration biopsy cytology (ABC) disclosed many characteristic figures that were similar to a bunch of grapes, secondary mucous globular structures (MGSs) and clustered MGSs. The MGS was a unit structure of secretory carcinoma composed of a centrally located, small amount of mucus and two or more tumor cells covering it. Other findings were vacuolated cells and mucus in a clear background.

[Continuous intra-arterial infusion chemotherapy for inoperable retroperitoneal liposarcoma--a case report].

A case of an inoperable recurrent retroperitoneal liposarcoma, histologically diagnosed as being a mixed myxoid type and a round cell type, which was treated by continuous intra-arterial infusion chemotherapy, is reported. The authors applied this treatment method using adriamycin and 5-FU via the feeding arteries, i.e.