Boron phenyl alanine targeted chitosan-PNIPAAm core-shell thermo-responsive nanoparticles: boosting drug delivery to glioblastoma in BNCT.

Boron neutron capture therapy (BNCT) is one of the best treatment modalities for glioblastoma multiform that could selectively kill the tumor cells. To be successful in BNCT, it is crucial to have enough B in the tumor. l-boron phenylalanine (l-BPA) targeted thermo-responsive core-shell nanoparticles (NPs) of chitosan-poly(N-isopropylacrylamide) (PNIPAAm) were our idea for endocytosis via sialic acid receptors, and selective delivery of B to glial cells.

Boron phenyl alanine targeted ionic liquid decorated chitosan nanoparticles for mitoxantrone delivery to glioma cell line.

Nanotechnology has revolutionized drug delivery in cancer treatment. In this study, novel efficient pH-responsive boron phenylalanine (BPA) targeted nanoparticles (NPs) based on ionic liquid modified chitosan have been introduced for selective mitoxantrone (MTO) delivery to the U87MG glioma cells. Urocanic acid (UA) and imidazolium (Im) based ionic liquids were used for structural modification simultaneously.

Evaluation of effectiveness of equivalent dose during proton boron fusion therapy (PBFT) for brain cancer: A Monte Carlo study.

Recently it has been suggested that the presence of boron-11 during proton therapy leads to a significant dose increasement in the BUR. Three high-LET alpha particles with an average energy of 4 MeV are generated at the point of interaction between proton and boron-11. Nevertheless, the cross-section of p+B11→3α interaction is negligible and dose increasement is unlikely.

Investigation of deep-seated brain tumor treatment based on Tehran research reactor new boron neutron capture therapy facility.

Aim: The main objective of this study is to evaluate the new proposed boron neutron capture therapy (BNCT) neutron beam based on the use of Tehran Research Reactor medical room to treat deep-seated brain tumors.

Material And Methods: The Snyder head phantom has been simulated through the MCNPX Monte Carlo code to calculate different dose profiles and desired medical merits. The simulation consists of the full geometry of new beamline and the phantom.

Analysis of the caregiver effective dose during I-131 therapy of thyroid.

Aims: The main objective of the present research is to analyze the caregiver effective dose during I-131 therapy of thyroid in some different situations using MCNP4C Monte Carlo code.

Patients And Methods: Two separate whole body Medical Internal Radiation Dosimetry (MIRD) phantoms have been defined simultaneously in a single Monte Carlo N-Particle (MCNP) input file as the patient and the caregiver. Two different groups of irradiation situations have been assumed for the caregiver related to the patient, (1) both the patient and the caregiver are standing and (2) the patient is lying in the bed while the caregiver is standing beside the patient.