Publications by authors named "Y Kasamatsu"
Article Synopsis
- The study investigates the effectiveness and patient satisfaction of long-acting antiretroviral therapy (ART) using cabotegravir (CAB) and rilpivirine (RPV) for individuals living with HIV who switched from conventional treatments.
- Thirty-eight male participants were monitored for 44 weeks after switching, with results showing that all maintained viral suppression and experienced increased treatment satisfaction.
- Additionally, the method demonstrated a small decrease in creatinine levels while lipid and glucose profiles remained stable, suggesting long-acting ART may enhance both health outcomes and patient well-being.
The radioisotope thorium-229 (Th) is renowned for its extraordinarily low-energy, long-lived nuclear first-excited state. This isomeric state can be excited by vacuum ultraviolet (VUV) lasers and Th has been proposed as a reference transition for ultra-precise nuclear clocks. To assess the feasibility and performance of the nuclear clock concept, time-controlled excitation and depopulation of the Th isomer are imperative.
View Article and Find Full Text PDFThe hydration structure of No, the divalent cation of nobelium in water, was investigated by ab initio molecular dynamics (MD) simulations. First, a series of benchmark calculations were performed to validate the density functional theory (DFT) calculation methods for a molecule containing a No atom. The DFT-MD simulation of the hydration structure of No was conducted after the MD method was validated by simulating the hydration structures of Ca and Sr, whose behavior was previously reported to be similar to that of No.
View Article and Find Full Text PDFBackground: Increased incidence of lifestyle diseases as side-effects of antiretroviral therapy (ART) have been reported in people living with HIV (PLWH). Few studies have evaluated obesity and hidden obesity in Japanese PLWH and their association with ART. In order to provide more appropriate drug selection and lifestyle guidance, we investigated the relationship between the effects of HIV infection and ART on the body composition of Japanese PLWH.
View Article and Find Full Text PDFIntroduction: Various therapeutic agents are being developed for the treatment of coronavirus disease 2019 (COVID-19). Therefore, it is crucial to accumulate information regarding the features of drug-resistant viruses to these antiviral drugs.
Methods: We investigated the emergence of dual-drug resistance in a kidney transplant recipient who received sotrovimab (from day 0) and remdesivir (RDV) (from day 8 to day 17).