Publications by authors named "Y Kalish"
Background: The risk of thrombosis increases after SARS-CoV-2 infection. This study aimed to assess associations between pre-infection anticoagulant exposure and SARS-CoV-2 infection-related outcomes in a population-based cohort.
Methods: Members of the "Meuhedet" health maintenance organization aged >45 years who tested positive for SARS-CoV-2 infection (03/2020-04/2022) were followed.
Article Synopsis
- Neurogenic thoracic outlet syndrome (NTOS) is caused by dynamic compression of the brachial plexus, with this study examining the link between a specific muscle deformity (CDAS) seen in MRI and vascular compression found during surgery.
- The study analyzed 44 patients who underwent surgery after failed rehabilitation, identifying two main types of NTOS: pure neurogenic (type A) and mixed neurogenic-vascular (type B), with type B further divided into three subtypes based on the nature of vascular compression.
- Findings showed that CDAS was more frequently associated with mixed types (especially type B1) and that patients with vascular variants exhibited more significant symptoms related to nerve compression compared to those with pure neurogenic NT
Circulating cell-free DNA (cfDNA) fragments are a biological analyte with extensive utility in diagnostic medicine. Understanding the source of cfDNA and mechanisms of release is crucial for designing and interpreting cfDNA-based liquid biopsy assays. Using cell type-specific methylation markers as well as genome-wide methylation analysis, we determine that megakaryocytes, the precursors of anuclear platelets, are major contributors to cfDNA (~26%), while erythroblasts contribute 1-4% of cfDNA in healthy individuals.
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- The study aimed to assess whether monitoring anti-Xa levels and adjusting enoxaparin doses in pregnant women could reduce complications related to the placenta during pregnancy.
- Out of 585 women evaluated, 110 were included, with significant differences in dosage adjustments and outcomes between the group receiving anti-Xa monitoring and the control group who were dosed by weight only.
- Results indicated that monitored women had more term deliveries and showed trends toward larger birth weights and fewer complications, but larger studies are necessary to confirm these findings.