Publications by authors named "Y Kairkhanova"
At the detonation of the atomic bombing in Hiroshima and Nagasaki, a significant amount of radionuclides was produced by the neutron induced activation. The residual radiation from the explosion is crucial to the health risk of the people who entered these cities after the bombing and might have inhaled these radioactive materials. Because 56Mn is one of the major radionuclides produced in soil and have not been studied until now, we had conducted a series of experiments using rats to investigate the biological impacts of exposure of 56MnO2 particles.
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- The study investigates the effects of radioactive manganese-56 dioxide (MnO) on liver function in male Wistar rats, noting a potential link to liver damage based on previous blood chemistry findings.
- Rats were exposed to MnO at varying doses and compared with a control group, revealing no significant liver damage but increased expression of certain liver genes related to stress response and cell cycle regulation.
- The findings suggest that even low doses of internal MnO exposure can induce short-term adaptive gene expression changes similar to those caused by higher external radiation, without affecting inflammation or fibrosis-related genes.
The experiment was performed in support of a Japanese initiative to investigate the biological effects of irradiation from residual neutron-activated radioactivity that resulted from the A-bombing. Radionuclide Mn (T = 2.58 h) is one of the main neutron-activated emitters during the first hours after neutron activation of soil dust particles.
View Article and Find Full Text PDFObjective: The pathological effects of internal exposure to manganese dioxide-56 (MnO) radioisotope particles have been previously examined in rats. Here we further examine the effects of MnO, focusing on changes in blood parameters.
Materials And Methods: Ten-week-old male Wistar rats were exposed to 3 doses of neutron-activated MnO powder, nonradioactive MnO powder, or external 60Co γ-rays (1 Gy, whole body).
Manganese-56 (56Mn) is among the predominant radioisotopes produced in soil by neutrons from atomic bombs. Previously, we examined the effects of the internal exposure of this radioisotope in Wistar rats and reported significant pathological changes in the lung and small intestine. In the present study, we focused on its effects on hyaluronan synthase 2 (Has2) gene expression that may related to pathological changes in the lung.
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