Publications by authors named "Y Kahlert"
Article Synopsis
- The study aims to understand how specific molecular changes, particularly the expression of a certain gene, influence the clinical outcomes of patients with pulmonary carcinoids, which can range from slow-growing to deadly tumors.
- Researchers analyzed RNA sequencing data from two cohorts of pulmonary carcinoid patients (totaling 193) to determine the prognostic value of this gene expression and its relationship with telomerase activity, which is linked to tumor aggressiveness.
- Results showed that high expression of the gene correlates with worse survival rates and is an independent predictor of poor clinical outcomes, suggesting that it could be a key factor in assessing the severity of pulmonary carcinoids.
Background: Telomere maintenance mechanisms (TMM) are a hallmark of high-risk neuroblastoma, and are conferred by activation of telomerase or alternative lengthening of telomeres (ALT). However, detection of TMM is not yet part of the clinical routine, and consensus on TMM detection, especially on ALT assessment, remains to be achieved.
Methods: Whole genome sequencing (WGS) data of 68 primary neuroblastoma samples were analyzed.
Article Synopsis
- Neuroblastomas, particularly those with high risk, often express telomerase activity, and compounds like 6-thio-2'-deoxyguanosine (6-thio-dG) can hinder the growth of these cancer cells.
- The study tested combinations of 6-thio-dG with traditional cancer drugs (etoposide, doxorubicin, ceritinib) on various neuroblastoma cell lines and mouse xenograft models, finding strong anti-tumor effects from 6-thio-dG combined with etoposide or doxorubicin, but not with ceritinib.
- The findings suggest that targeting telomerase can enhance the effectiveness of existing chemotherapy drugs, indicating a potential
The mechanisms behind the evolution of complex genomic amplifications in cancer have remained largely unclear. Using whole-genome sequencing data of the pediatric tumor neuroblastoma, we here identified a type of amplification, termed 'seismic amplification', that is characterized by multiple rearrangements and discontinuous copy number levels. Overall, seismic amplifications occurred in 9.
View Article and Find Full Text PDFPurpose: Telomere maintenance is a hallmark of high-risk neuroblastoma; however, the contribution of telomerase and alternative lengthening of telomeres (ALT) to clinical phenotypes has remained unclear. We aimed to determine the clinical relevance of telomerase activation versus ALT as biomarkers in pretreatment neuroblastoma and to assess the potential value of telomerase as a therapeutic target.
Materials And Methods: The genomic status of and was assessed in 457 pretreatment neuroblastomas by fluorescence in situ hybridization.