Increased Non-Relapse Mortality in Older People With Allogeneic Hematopoietic Stem Cell Transplantation Using Fludarabine and Myeloablative Dose of Busulfan-Based Regimen.

Fludarabine and myeloablative busulfan (FluBu4) in allogeneic hematopoietic stem cell transplantation (HSCT) for older people have not been adequately examined. This retrospective study analyzed data from a large-scale, nationwide database in Japan. Adult patients (> 15 years old, y/o) who received their first HSCT with FluBu4 for hematological malignancies were included.

Mechanical finite element analysis of needle tip shape to develop insertable polymer-based microneedle without plastic deformation.

Bioabsorbable polymer microneedles are highly attractive as modernized medical devices for efficient yet safe transdermal drug delivery and biofluid biopsy. In this study, the elastoplastic deformation of polymer microneedles, having a high aspect ratio (over 5-10), is investigated using poly(lactic) acid polymer approved by the United States Food and Drug Administration to be generally considered safe. Microneedle geometries are comprehensively analyzed for tip geometries comprising the tip diameter (ϕ) and tip taper length (l) of 100 designs.

Risk-Adapted Letermovir Prophylaxis Based on a Scoring System Predicting a Higher Burden of Cytomegalovirus Exposure After Allogeneic Hematopoietic Cell Transplantation.

We previously reported that the area under the curve of log-transformed cytomegalovirus antigenemia (CMV-AUC) until 100 days after allogeneic hematopoietic cell transplantation (allo-HCT) was associated with an increased risk of non-relapse mortality. We applied a risk-adapted letermovir (LTV) prophylaxis strategy guided by a risk score that predicts a higher CMV-AUC. First, we retrospectively analyzed 278 allo-HCT recipients between 2007 and 2017 (Period 1).

Impacts of donor age and HLA mismatch on HCT outcomes differ according to the donor CMV serostatus in unrelated allo-HCT.

In unrelated allogeneic hematopoietic cell transplantation (allo-HCT), older and/or HLA-mismatched donors are known risk factors for survival outcomes. In healthy individuals, cytomegalovirus (CMV) seropositivity is associated with impaired adaptive immune systems. We assessed whether the adverse effects of donor risk factors are influenced by the donor CMV serostatus.

Support Desired by Parents of Infants With Hearing Impairments Diagnosed Through Newborn Hearing Screening: A Questionnaire-Based Survey.

Objective We aimed to highlight problems faced by parents of infants diagnosed with hearing impairment upon newborn hearing screening (NHS) and to suggest how support might be improved. Methods We distributed a questionnaire to explore difficulties encountered by parents when seeking support, whether they were satisfied with the support, and their unmet needs. We enrolled 101 parents of infants with hearing impairments diagnosed upon NHS (hearing levels: 7.